# Architects of folding, editors of immunity: the strategic use of N-glycans in vaccine design

**Authors:** Sofia Orioli, Tommy Idrovo-Hidalgo, Maria de los Angeles Martinez Saucedo, Cecilia D’Alessio

PMC · DOI: 10.3389/fimmu.2026.1766701 · Frontiers in Immunology · 2026-02-18

## Full-text entities

- **Genes:** BACE2 (beta-secretase 2) [NCBI Gene 25825] {aka AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13}, CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}, EPO (erythropoietin) [NCBI Gene 2056] {aka DBAL, ECYT5, EP, MVCD2}, ENPEP (glutamyl aminopeptidase) [NCBI Gene 2028] {aka APA, CD249, gp160}, MOGS (mannosyl-oligosaccharide glucosidase) [NCBI Gene 7841] {aka CDG2B, CWH41, DER7, GCS1}, MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase) [NCBI Gene 4245] {aka GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, GnTI}
- **Diseases:** MOGS-CDG (MESH:C567859), congenital disorders of glycosylation (MESH:D018981), infectious diseases (MESH:D003141), influenza (MESH:D007251), infection (MESH:D007239), delayed-type hypersensitivity (MESH:D006968)
- **Chemicals:** LPS (MESH:D008070), Man5GlcNAc2 (MESH:C058642), asparagine (MESH:D001216), oligosaccharide (MESH:D009844), sugars (MESH:D000073893), N-glycan (-), mannose (MESH:D008358), methanol (MESH:D000432), monosaccharides (MESH:D009005), carbohydrate (MESH:D002241), GlcNAc (MESH:D000117), Glycan (MESH:D011134), N (MESH:D009584)
- **Species:** Bacillus anthracis (anthrax bacterium, species) [taxon 1392], Nicotiana benthamiana (species) [taxon 4100], Cavia porcellus (domestic guinea pig, species) [taxon 10141], Campylobacter jejuni (species) [taxon 197], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Trichoderma reesei (species) [taxon 51453], Komagataella pastoris (species) [taxon 4922], Human immunodeficiency virus 1 (no rank) [taxon 11676], Arabidopsis thaliana (mouse-ear cress, species) [taxon 3702], Escherichia coli (E. coli, species) [taxon 562], Homo sapiens (human, species) [taxon 9606], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932], Mus musculus (house mouse, species) [taxon 10090], Mycobacterium tuberculosis (species) [taxon 1773]
- **Cell lines:** CHO — Cricetulus griseus (Chinese hamster), Spontaneously immortalized cell line (CVCL_0213), SuperMan5 — Mus musculus (Mouse), Transformed cell line (CVCL_5U93), insect — Trichoplusia ni (Cabbage looper), Spontaneously immortalized cell line (CVCL_C190)

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## References

87 references — full list in the complete paper: https://tomesphere.com/paper/PMC12957175/full.md

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Source: https://tomesphere.com/paper/PMC12957175