# Case Report: Syncope in an 11-year-old girl induced by anomalous aortic origin of the coronary artery, initially diagnosed via echocardiography

**Authors:** Juan Wang, Wenlong Wang, Xiaomei Li, Yuting Wu, Xiangqun Sun, Qian Liu, Dong Wang

PMC · DOI: 10.3389/fcvm.2026.1632958 · Frontiers in Cardiovascular Medicine · 2026-02-18

## TL;DR

An 11-year-old girl with a rare heart condition causing fainting was diagnosed using echocardiography, emphasizing the importance of early imaging for such anomalies.

## Contribution

This case emphasizes the role of echocardiography as a first-line diagnostic tool for anomalous aortic origin of the coronary artery.

## Key findings

- AAOCA was diagnosed in an 11-year-old girl presenting with syncope and myocardial infarction.
- Echocardiography proved effective in identifying the coronary anomaly in this case.
- The case underscores the need for comprehensive coronary artery evaluation using high-quality imaging.

## Abstract

Anomalous aortic origin of the coronary artery (AAOCA) is a relatively rare congenital coronary anomaly identified as a common cause of exercise-induced cardiac syncope and sudden death in young individuals. In most cases, the coronary artery courses between the aorta and pulmonary artery, exhibiting an intramural trajectory within the aortic wall. Herein, we present a case of an 11-year-old girl with AAOCA manifesting with sudden-onset syncope complicated by myocardial infarction as the initial symptom, along with a discussion of the underlying pathogenesis. This case is important as it highlights the fact that comprehensive coronary artery evaluation combined with high-quality imaging modalities is critical to enhance the diagnostic accuracy of coronary anomalies. As such, TTE should be established as an important first-line tool within a multimodality imaging pathway. for AAOCA.

## Linked entities

- **Diseases:** myocardial infarction (MONDO:0005068)

## Full-text entities

- **Genes:** MB (myoglobin) [NCBI Gene 4151] {aka MYOSB, PVALB}, TNNI3 (troponin I3, cardiac type) [NCBI Gene 7137] {aka CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI}, CMPK1 (cytidine/uridine monophosphate kinase 1) [NCBI Gene 51727] {aka CK, CMK, CMPK, UMK, UMP-CMPK, UMPK}
- **Diseases:** mitral regurgitation (MESH:D008944), luminal stenosis (MESH:D003251), coronary ischemia (MESH:D007511), arrhythmic (OMIM:212500), electrical disturbances (MESH:D004556), coronary structural anomalies (MESH:C536503), cardiomyopathy (MESH:D009202), myocarditis (MESH:D009205), sudden cardiac death (MESH:D016757), left ventricular wall (MESH:D018487), echocardiographic structural abnormalities (MESH:C566527), primary arrhythmias (MESH:D001145), ST-T segment abnormalities (MESH:D000072657), ischemic necrosis (MESH:D005271), cardiogenic shock (MESH:D012770), ischemic (MESH:D002545), inflammatory (MESH:D007249), anatomical abnormalities (MESH:D020763), Syncope (MESH:D013575), herpes (MESH:C536395), coronary (MESH:D003323), ventricular tachycardia (MESH:D017180), R-AAOCA (MESH:C535681), myocardial necrosis (MESH:D009336), hypoplastic (MESH:D000741), anterior MI (MESH:D056988), myocardial pathology (MESH:D005598), coronary artery malformation (MESH:D003324), infarction (MESH:D007238), Anomalous aortic origin of the coronary artery (MESH:D000080038), congenital coronary anomaly (MESH:D003330), sudden death (MESH:D003645), MI (MESH:D009203), myocardial ischemia (MESH:D017202), abnormalities (MESH:D000014)
- **Chemicals:** oxygen (MESH:D010100)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12957173/full.md

## References

25 references — full list in the complete paper: https://tomesphere.com/paper/PMC12957173/full.md

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Source: https://tomesphere.com/paper/PMC12957173