# Non-sensorimotor symptoms in chronic inflammatory demyelinating polyneuropathy

**Authors:** Fabian Klostermann, Oliver L. Steiner

PMC · DOI: 10.1007/s00415-026-13725-0 · Journal of Neurology · 2026-03-03

## TL;DR

This paper discusses non-sensorimotor symptoms in CIDP, suggesting a broader impact than previously thought.

## Contribution

The paper highlights the need for a holistic approach to CIDP due to the prevalence of non-sensorimotor symptoms.

## Key findings

- CIDP is associated with autonomic, circadian, fatigue, mood, and cognitive dysfunctions.
- Non-sensorimotor symptoms challenge the traditional view of CIDP as a PNS-only disease.
- A holistic assessment is needed to improve therapeutic outcomes in CIDP patients.

## Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is defined as a dysimmune disorder of the peripheral nervous system (PNS) resulting in sensorimotor deficits. However, an increasing body of data suggests that CIDP also goes along with features, such as autonomic, circadian, fatigue, mood, and subtle cognitive dysfunctions. Some of these non-sensorimotor symptoms (NSMS) challenge the concept of an exclusive PNS disease. Pragmatically, the high prevalence of NSMS calls for a more holistic disease assessment and surveillance to achieve optimal therapeutic results.

## Linked entities

- **Diseases:** chronic inflammatory demyelinating polyneuropathy (MONDO:0006702), CIDP (MONDO:0006702)

## Full-text entities

- **Genes:** PMP22 (peripheral myelin protein 22) [NCBI Gene 5376] {aka CIDP, CMT1A, CMT1E, DSS, GAS-3, GAS3}, FCGRT (Fc gamma receptor and transporter) [NCBI Gene 2217] {aka FCRN, FcgammaRn, alpha-chain}
- **Diseases:** Autonomic neuropathy (MESH:D009422), facial palsy (MESH:D005158), cognitive deficit (MESH:D003072), axonal damage (MESH:D001480), dysimmune disorder (MESH:D009358), autonomic (MESH:D001342), tongue fasciculations (MESH:D005207), autonomic abnormalities (MESH:D009461), gastrointestinal, genitourinary, or orthostatic problems (MESH:D000091642), MS (MESH:D009103), sensorimotor neuropathy (MESH:C537197), neurogenic dysfunction of the musculus rectus abdominis (MESH:D020434), Fatigue (MESH:D005221), PNS disease (MESH:D010523), fragmentation of sleep (MESH:D012892), motor neuron disease (MESH:D016472), gain-of-dysfunction (MESH:D015430), NSMS (MESH:D020233), mood change (MESH:D019964), neuropathic complaints (MESH:D009437), neurological diseases (MESH:D020271), depression (MESH:D003866), paresis (MESH:D010291), numbness (MESH:D006987), nerve edema (MESH:D004487), atrophy (MESH:D001284), neuroinflammation (MESH:D000090862), essential tremor (MESH:D020329), CIP (MESH:D011129), consciousness loss (MESH:D014474), cognitive abnormalities (MESH:D060825), optic neuritis (MESH:D009902), polyneuropathies (MESH:D011115), diabetic (MESH:D003920), sexual dysfunctions (MESH:D012735), CCPD (MESH:D003711), Pain (MESH:D010146), daytime sleepiness (MESH:D012893), vision loss (MESH:D014786), dystonic tremor (MESH:D014202), hypoventilation (MESH:D007040), CIDP (MESH:D020277), papilledema (MESH:D010211), neurodegeneration (MESH:D019636), inflammation (MESH:D007249), loss (MESH:D016388), micturitional disturbance (MESH:D013575)
- **Chemicals:** steroid (MESH:D013256), cortisone (MESH:D003348), efgartigimod (MESH:C000718373)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12956916/full.md

---
Source: https://tomesphere.com/paper/PMC12956916