# Male Breast Cancer: Growing Insights and Continuing Challenges

**Authors:** Sahar Iftikhar, Elissa Burr, Amal Freigoun, Theo Nearney, Christelle Q. Kanda, Hazel Robinson, Caroline Vermeren, Udana Wickramaratne, Matthew Everest, Luca Foley, Valerie Speirs

PMC · DOI: 10.1002/cam4.71673 · Cancer Medicine · 2026-03-03

## TL;DR

Male breast cancer is rare but increasing, with challenges in awareness and timely diagnosis due to stigma and gendered perceptions.

## Contribution

The paper reviews current insights into male breast cancer, highlighting the impact of stigma and awareness on diagnosis and prognosis.

## Key findings

- Male breast cancer shares features with female BC but differs in presentation and tumor biology.
- Men often present at later stages due to low awareness and stigma.
- Improved education and research are needed to enhance early detection and outcomes.

## Abstract

Breast cancer (BC) in men accounts for less than 1% of all BC diagnoses worldwide. Despite its low incidence, the number of men being diagnosed is increasing. Historically perceived as a predominantly female disease, BC in men has received comparatively limited attention.

This review aims to examine how BC manifests in men and explored the impact of stigma and awareness on diagnosis and prognosis.

A narrative review of current literature was undertaken, including epidemiological studies, clinical research and psychosocial analyses relating to male BC.

Male BC shares several pathological and molecular features with female BC, but notable differences exist in presentation, tumour biology and treatment considerations. Men are more likely to present at a later stage of disease, often due to low awareness and misconception that BC affects only women. Stigma and limited targeted education further contribute to delayed medical consultation.

Although understanding of male BC has improved, challenges remain in early detection and awareness. The gendered perception of BC may discourage men from seeking timely medical advice, leading to more advanced disease at diagnosis and potentially poorer outcomes.

Addressing stigma, increasing public and professional education and promoting clinical research inclusive of men are essential to improving timely diagnosis and outcomes.

## Linked entities

- **Diseases:** breast cancer (MONDO:0004989)

## Full-text entities

- **Genes:** EREG (epiregulin) [NCBI Gene 2069] {aka EPR, ER, Ep}, CYP19A1 (cytochrome P450 family 19 subfamily A member 1) [NCBI Gene 1588] {aka ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX}, CHEK2 (checkpoint kinase 2) [NCBI Gene 11200] {aka CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53}, TOX3 (TOX high mobility group box family member 3) [NCBI Gene 27324] {aka CAGF9, TNRC9}, ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19}, RAD51B (RAD51 paralog B) [NCBI Gene 5890] {aka R51H2, RAD51L1, REC2}, PALB2 (partner and localizer of BRCA2) [NCBI Gene 79728] {aka BROVCA5, FANCN, PNCA3}, BRCA1 (BRCA1 DNA repair associated) [NCBI Gene 672] {aka BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4}, BRCA2 (BRCA2 DNA repair associated) [NCBI Gene 675] {aka BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD}, PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) [NCBI Gene 5290] {aka CCM4, CLAPO, CLOVE, CWS5, HMH, MCAP}
- **Diseases:** anxiety (MESH:D001007), sexual function (MESH:D050035), Cancer (MESH:D009369), DCIS (MESH:D002285), sexual dysfunction (MESH:D012735), shock (MESH:D012769), disease (MESH:D004194), male BCs (MESH:D005832), Testicular Cancer (MESH:D013736), diarrhoea (MESH:D003967), gynecomastia (MESH:D006177), obesity (MESH:D009765), advanced disease (MESH:D020178), Male BC (MESH:D018567), death (MESH:D003643), gonadal suppression (MESH:D006058), IDC (MESH:D044584), Breast cancer (MESH:D001943)
- **Chemicals:** alpelisib (MESH:C585539), tamoxifen (MESH:D013629), fulvestrant (MESH:D000077267), abemaciclib (MESH:C000590451), metformin (MESH:D008687), GnRHa (-), anastrozole (MESH:D000077384), ribociclib (MESH:C000589651)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** P13K

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12956834/full.md

## References

70 references — full list in the complete paper: https://tomesphere.com/paper/PMC12956834/full.md

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Source: https://tomesphere.com/paper/PMC12956834