# Evaluation of chemerin levels in the pathogenesis of psoriasis

## TL;DR

This study found higher chemerin levels in psoriasis patients compared to healthy individuals, suggesting a potential role in the disease's inflammation.

## Contribution

The study demonstrates a significant elevation of chemerin levels in psoriasis patients and links it to inflammatory markers.

## Key findings

- Serum chemerin levels were significantly higher in psoriasis patients than in controls.
- Chemerin levels correlated positively with C-reactive protein and platelet levels in psoriasis patients.
- No significant correlation was found between chemerin levels and disease severity scores.

## Abstract

Psoriasis is a complex, chronic, inflammatory condition which affects skin, nails and joints. In our study, we enrolled fifty patients with psoriasis and twenty-eight healthy individuals. Serum samples were collected both from the psoriatic patients (study group) and patients with an inguinal hernia (control group). The level of chemerin in the serum was measured by enzyme-linked immunosorbent assay. In the current research we noticed that serum chemerin concentration was significantly higher in the patients suffering from psoriasis in comparison to the controls. Importantly, we observed a positive, statistically significant correlation between the serum chemerin levels and C-reactive protein, as well as chemerin levels and platelets in the serum of patients affected by psoriasis. However, we did not observe a significant correlation between chemerin level and the Psoriasis Area and Severity Index score. To sum up, our results revealed that chemerin levels vary significantly in the serum of patients with psoriasis in contrast to the control group.