# Brain sparing and the blood brain barrier—bridging the preclinical to clinical gap

**Authors:** Tegan A. White, Suzanne L. Miller

PMC · DOI: 10.1038/s41390-025-04479-y · Pediatric Research · 2025-10-02

## Full-text entities

- **Genes:** ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}, CLDN5 (claudin 5) [NCBI Gene 7122] {aka AWAL, BEC1, CPETRL1, TMDVCF, TMVCF}, CLDN12 (claudin 12) [NCBI Gene 9069], OCLN (occludin) [NCBI Gene 100506658] {aka BLCPMG, PPP1R115, PTORCH1}
- **Diseases:** placental dysfunction (MESH:D010922), cerebrovascular compromise (MESH:D002561), placental insufficiency (MESH:D010927), Brain sparing (MESH:D001927), brain injury (MESH:D001930), neurodevelopmental deficits (MESH:D009461), hypoxemia (MESH:D000860), fetal hypoxia (MESH:D005311), IVH (MESH:D000074042), hypoxic (MESH:D002534), fetal brain sparing (MESH:D005315), BBB (MESH:C536830), FGR (MESH:D005317)
- **Chemicals:** oxygen (MESH:D010100)
- **Species:** Cavia porcellus (domestic guinea pig, species) [taxon 10141], Homo sapiens (human, species) [taxon 9606], Ovis aries (domestic sheep, species) [taxon 9940]

## Full text

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Source: https://tomesphere.com/paper/PMC12956597