# Papillophlebitis Presenting As Optic Disc Edema Following Cervical Manipulation: A Case Report

**Authors:** Hisanori Miyashita, Eri Shibuya, Hiroshi Sasaki, Eri Kubo

PMC · DOI: 10.7759/cureus.102793 · Cureus · 2026-02-01

## TL;DR

An older woman developed optic disc swelling after cervical manipulation, diagnosed as papillophlebitis, and recovered fully with corticosteroids.

## Contribution

Demonstrates that papillophlebitis can occur in older adults and may be triggered by transient circulatory stress.

## Key findings

- Cervical manipulation may trigger papillophlebitis in older individuals.
- Corticosteroid therapy led to rapid resolution of optic disc edema and visual field recovery.
- Imaging ruled out intracranial hypertension and venous sinus thrombosis.

## Abstract

Papillophlebitis is an uncommon inflammatory disorder of the retinal venous system that typically affects young adults but can also present in older individuals. We report the case of a 68-year-old woman who developed unilateral optic disc edema following cervical manipulation. The best-corrected visual acuity was 20/20 and 20/13 in the right and left eyes, respectively, with no relative afferent pupillary defect. Fluorescein angiography revealed disc leakage without capillary nonperfusion, and optical coherence tomography showed marked peripapillary retinal nerve fiber layer thickening without macular involvement. Brain and orbital magnetic resonance imaging revealed no abnormalities, including intracranial hypertension or venous sinus thrombosis. Based on the clinical and imaging findings, papillophlebitis was diagnosed, and oral corticosteroid therapy was initiated, resulting in the rapid resolution of disc edema and normalization of visual field findings within one month. This case highlights that a clinical picture highly suggestive of papillophlebitis can occur in older adults, potentially triggered by transient circulatory stress, and underscores the effectiveness of corticosteroid therapy in achieving complete anatomical and functional recovery of the optic nerve.

## Full-text entities

- **Genes:** ACE (angiotensin I converting enzyme) [NCBI Gene 1636] {aka ACE1, CD143, DCP, DCP1}, AP2B1 (adaptor related protein complex 2 subunit beta 1) [NCBI Gene 163] {aka ADTB2, AP105B, AP2-BETA, CLAPB1}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, AQP4 (aquaporin 4) [NCBI Gene 361] {aka MIWC, MLC4, WCH4, hAQP4}
- **Diseases:** autoimmune antibodies (MESH:D001327), hemorrhage (MESH:D006470), disc (MESH:D055959), intracranial hypertension (MESH:D019586), Stroke (MESH:D020521), retinal venous congestion (MESH:D006940), retinal venous disease (MESH:D012164), venous disorders (MESH:D014647), neuromyelitis optica spectrum disorder (MESH:D009471), visual field defect (MESH:D005128), Cervical Manipulation (MESH:D002575), infectious (MESH:D003141), mass lesions (MESH:C536030), inflammatory optic disc (MESH:D009901), CRVO (MESH:D012170), thrombotic (MESH:D013927), syphilis (MESH:D013587), anterior ischemic optic neuropathy (MESH:D018917), ODE (MESH:D010211), inflammation (MESH:D007249), giant cell arteritis (MESH:D013700), afferent pupillary defect (MESH:D011681), atherosclerotic cardiovascular disease (MESH:D050197), venous outflow impairment (MESH:D006502), disc leakage (MESH:D003763), demyelination (MESH:D003711), pain (MESH:D010146), intracranial abnormalities (MESH:D001927), optic nerve head swelling (MESH:D006259), hypertension (MESH:D006973), venous occlusion (MESH:D001157), ischemic (MESH:D002545), ANCA (MESH:D056648), ischemic retinal changes (MESH:D012173), diabetes mellitus (MESH:D003920), retinal hemorrhage (MESH:D012166), venous sinus thrombosis (MESH:D012851), venous dilation (MESH:D002311), optic neuritis (MESH:D009902), papillary edema (MESH:D004487), numbness (MESH:D006987), visual distortions (MESH:D006311), pain with eye movement (MESH:D058447)
- **Chemicals:** steroid (MESH:D013256), prednisolone (MESH:D011239), Fluorescein (MESH:D019793)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12956486/full.md

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Source: https://tomesphere.com/paper/PMC12956486