# Will animal reservoirs give us the next SARS-CoV-2 variant?

**Authors:** Davey Smith

PMC · DOI: 10.1371/journal.ppat.1014008 · PLOS Pathogens · 2026-03-03

## Full-text entities

- **Genes:** ACE2 (angiotensin converting enzyme 2) [NCBI Gene 59272] {aka ACEH}, S (surface glycoprotein) [NCBI Gene 43740568] {aka spike glycoprotein}, TMPRSS2 (transmembrane serine protease 2) [NCBI Gene 7113] {aka PRSS10}, HLA-C (major histocompatibility complex, class I, C) [NCBI Gene 3107] {aka D6S204, HLA-JY3, HLAC, HLC-C, MHC, PSORS1}
- **Diseases:** SARS-CoV-2 infections (MESH:D000086382), Infected (MESH:D007239)
- **Species:** Sus scrofa (pig, species) [taxon 9823], H1N1 subtype (serotype) [taxon 114727], Neogale vison (American mink, species) [taxon 452646], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Orthocoronavirinae (subfamily) [taxon 2501931], Mus musculus (house mouse, species) [taxon 10090], Canis lupus familiaris (dog, subspecies) [taxon 9615], Equus caballus (domestic horse, species) [taxon 9796], Odocoileus virginianus (white-tailed deer, species) [taxon 9874], Cervidae (deer, family) [taxon 9850], Rattus norvegicus (brown rat, species) [taxon 10116], Homo sapiens (human, species) [taxon 9606], Felis catus (cat, species) [taxon 9685], Cricetinae (hamsters, subfamily) [taxon 10026], Chiroptera (bats, order) [taxon 9397]
- **Mutations:** L18F, L452M, Q954H, L1035F, M1229I, P597L, H245Y, Q314K, M474I, T434I, F486L, P812R, Y453F, L452R/Q, I692V, N501Y, A382V, E484D, N501T

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## References

34 references — full list in the complete paper: https://tomesphere.com/paper/PMC12956066/full.md

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Source: https://tomesphere.com/paper/PMC12956066