# Reactive granulomatous dermatitis arising in the setting of interleukin-17 inhibition successfully treated with tofacitinib

**Authors:** Sarah L. Spaulding, A. Mitchel Wride, Michael J. Murphy, Muhammad H. Junejo, William Damsky

PMC · DOI: 10.1016/j.jdcr.2025.09.043 · JAAD Case Reports · 2025-10-14

## Full-text entities

- **Genes:** mucin [NCBI Gene 100508689], TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, IL17A (interleukin 17A) [NCBI Gene 3605] {aka CTLA-8, CTLA8, IL-17, IL-17A, IL17, ILA17}
- **Diseases:** granulomatous dermatitis (MESH:D003872), rash (MESH:D005076), pleural effusion (MESH:D010996), cutaneous (MESH:D018366), granulomatous disorders (MESH:D006105), systemic lupus erythematosus (MESH:D008180), RGD (MESH:D000085343), psoriatic arthritis (MESH:D015535), psoriasis (MESH:D011565), granulomatous skin diseases (MESH:D012871), granulomatous inflammation (MESH:D007249), hyperlipidemia (MESH:D006949), Diabetes (MESH:D003920), papules (MESH:D000169), type 2 diabetes mellitus (MESH:D003924), Digestive and Kidney Diseases (MESH:D007674), MGUS (MESH:D008998), hypertension (MESH:D006973), inflammatory arthritis (MESH:D001168), GA (MESH:D016460), Crohn's disease (MESH:D003424), eruption (MESH:D003875), gammopathy (MESH:D010265), sarcoidosis (MESH:D012507)
- **Chemicals:** Methotrexate (MESH:D008727), adalimumab (MESH:D000068879), secukinumab (MESH:C555450), Risankizumab (MESH:C000601773), triamcinolone (MESH:D014221), Tofacitinib (MESH:C479163), eosin (MESH:D004801), amlodipine (MESH:D017311), Hematoxylin (MESH:D006416), RGD (-), Apremilast (MESH:C505730), deucravacitinib (MESH:C000628674)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12955564/full.md

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Source: https://tomesphere.com/paper/PMC12955564