# Prosthetic joint infection caused by Neisseria sicca/subflava

## TL;DR

A rare case of prosthetic joint infection caused by Neisseria sicca/subflava is reported, highlighting the importance of considering uncommon bacteria in such infections.

## Contribution

This case report adds to the limited literature on Neisseria sicca/subflava as a rare cause of prosthetic joint infection.

## Key findings

- Neisseria sicca/subflava was identified as the causative agent in a prosthetic joint infection.
- The patient showed clinical improvement after prosthesis explantation and targeted antibiotic therapy.

## Abstract

Prosthetic joint infections are most commonly caused by staphylococci and streptococci, while commensal Neisseria species are exceedingly rare etiologic agents.

We report a 71-year-old white male with multiple comorbidities who presented with progressive left knee pain 9 years after total knee arthroplasty. Synovial fluid analysis showed an elevated leukocyte count with neutrophil predominance, and cultures subsequently grew Neisseria sicca/subflava. Given the concern for prosthetic joint infection, he underwent prosthesis explantation and received intravenous ceftriaxone 2 g daily for 6 weeks. Poor dentition was identified as a suspected potential source of hematogenous seeding. The patient demonstrated clinical improvement with surgical intervention and targeted antimicrobial therapy.

Neisseria sicca/subflava should be recognized as a rare but clinically significant cause of prosthetic joint infection.