# Electrochemical Synthesis of 1,2-Substituted N‑Amido Benzimidazoles by Reduction of Nitroarenes

**Authors:** Daniel Doellerer, Aaron Schüll, Thomas Weyhermüller, Sebastian B. Beil, Siegfried R. Waldvogel

PMC · DOI: 10.1021/acs.orglett.5c05349 · Organic Letters · 2026-02-16

## TL;DR

This paper introduces a new electrochemical method to efficiently synthesize a rare type of benzimidazole compound with potential medical uses.

## Contribution

A novel electrochemical protocol for synthesizing 1,2-substituted N-amido benzimidazoles with high yields and functional group tolerance.

## Key findings

- The electrochemical method achieves target compounds in up to 89% yield.
- The protocol is safe, reliable, and tolerant to various functional groups.

## Abstract

Despite the vast
number of reports on benzimidazoles, 1,2-substituted N-amido benzimidazoles remain an underrepresented and scarcely
accessible compound class with promising pharmacological relevance.
We present a safe, reliable electrochemical protocol that provides
easy access to those structures. The reaction exhibits broad functional
group tolerance and affords the target compounds in ≤89% yields.

## Full-text entities

- **Genes:** PRMT5 (protein arginine methyltransferase 5) [NCBI Gene 10419] {aka HRMT1L5, HSL7, IBP72, JBP1, SKB1, SKB1Hs}
- **Diseases:** tumors (MESH:D009369), leukemia (MESH:D007938)
- **Chemicals:** benzaldehyde (MESH:C032175), omeprazole (MESH:D009853), 5-methyl furfural (MESH:C048065), N (MESH:D009584), oxalates (MESH:D010070), pyridines (MESH:D011725), carbon (MESH:D002244), amidines (MESH:D000578), esters (MESH:D004952), Benzohydrazide (MESH:C006712), o-phenylenediamines (MESH:C034193), telmisartan (MESH:D000077333), phenols (MESH:D010636), amine (MESH:D000588), methanol (MESH:D000432), benzimidazoles (MESH:D001562), -hydroxy heterocycles (-), Metal (MESH:D008670), nitriles (MESH:D009570), acids (MESH:D000143), alcohol (MESH:D000438), acetic acid (MESH:D019342), furfural (MESH:D005662), H (MESH:D006859), hydrazide (MESH:D006834), sodium acetate (MESH:D019346), astemizole (MESH:D016589), benzimidazole (MESH:C031000), Lead (MESH:D007854), phenylacetaldehyde (MESH:C013192), 2-nitrophenylhydrazine (MESH:C060574), sulfuric acid (MESH:C033158), aldehyde (MESH:D000447), carbendazim (MESH:C006698), lanthanoid (MESH:D028581), o-nitroaniline (MESH:C578169), formaldehyde (MESH:D005557), samarium (MESH:D012493), triazoles (MESH:D014230), 4-fluorobenzoic acid (MESH:C022893), vanillin (MESH:C100058), pyrroles (MESH:D011758)

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12954844/full.md

## References

48 references — full list in the complete paper: https://tomesphere.com/paper/PMC12954844/full.md

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Source: https://tomesphere.com/paper/PMC12954844