# Comparative Evaluation of Effectiveness of Oxygen-Releasing Gel With Scaling and Root Planing (SRP) With That of Scaling and Root Planing Alone in the Management of Chronic Periodontitis Patients: Study Protocol for Cross-Sectional Survey

**Authors:** Geeta Bhandari, Priyanka Jaiswal, Shweta Bhagat, Sakshi Kotecha

PMC · DOI: 10.2196/75795 · JMIR Research Protocols · 2026-03-02

## TL;DR

This study compares the effectiveness of adding an oxygen-releasing gel to a standard dental treatment for chronic periodontitis.

## Contribution

The novel contribution is evaluating the added benefit of an oxygen-releasing gel alongside scaling and root planing.

## Key findings

- Oxygen-releasing gel combined with SRP may improve healing and clinical outcomes in periodontitis.
- Clinical measurements like plaque index and probing depth will be compared between groups.
- The study uses a split-mouth design with 22 participants and 44 sites.

## Abstract

Gingival recession and periodontal pockets are the results of the gradual deterioration of the alveolar bone and periodontal ligament caused by periodontitis, which is caused by inflammation of the tissues supporting the tooth. The primary goal of periodontal therapy is to eradicate these aberrant traits. Despite being a popular treatment, scaling and root planing (SRP) has limitations, such as difficulty accessing deeper pockets and root concavities.

The aim of this study is to assess the effectiveness of oxygen-releasing gel as a supplement to nonsurgical treatment for chronic periodontitis.

Twenty-two systemically healthy people with sites of chronic periodontitis were the participants of a split-mouth randomized controlled experiment. For every patient, two locations were chosen and divided into two groups at random. In total, 44 sites were chosen and divided into two groups: Group I (the test group) consisted of 22 test sites, while Group II (the control group) consisted of 22 control sites. While group II underwent SRP alone, group I underwent SRP followed by the use of BlueM oral gel. Plaque index, full mouth bleeding score, clinical attachment level, and probing pocket depth were measured at baseline, one month, and three months, and were compared appropriately.

All the clinical measurements will be recorded. It can be anticipated that SRP followed by the use of BlueM oral gel will provide additional benefits in the management of chronic periodontitis by promoting better healing and clinical outcomes.

Within the constraints of this study, it can be anticipated that by encouraging improved healing and clinical results in chronic periodontitis, oxygen-releasing gel is more advantageous when used in conjunction with SRP than when SRP is done alone.

## Linked entities

- **Diseases:** chronic periodontitis (MONDO:0005593)

## Full-text entities

- **Genes:** TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, EGF (epidermal growth factor) [NCBI Gene 1950] {aka HOMG4, URG}
- **Diseases:** gingival bleeding (MESH:D005884), periodontal disease (MESH:D010510), allergies (MESH:D004342), toxicity (MESH:D064420), loss of alveolar bone (MESH:D016301), gingivitis (MESH:D005891), infections (MESH:D007239), Chronic Periodontitis (MESH:D055113), caries (MESH:D003731), Hypoxia (MESH:D000860), periodontal pockets (MESH:D010514), FMBS (MESH:D009059), Bleeding (MESH:D006470), hypoxic (MESH:D002534), recession (MESH:C565432), irritation (MESH:D001523), ischemic (MESH:D002545), PPD (MESH:D005888), generalized periodontitis (MESH:D010518), inflammation (MESH:D007249)
- **Chemicals:** PO2~ (MESH:C093415), ROS (MESH:D017382), lysine (MESH:D008239), alcohol (MESH:D000438), triclosan (MESH:D014260), cellulose gum (MESH:D002266), citric acid (MESH:D019343), carbohydrates (MESH:D002241), silica (MESH:D012822), glycerine (MESH:D005990), O3 (MESH:D010126), BlueM (-), H2O2 (MESH:D006861), lidocaine (MESH:D008012), curcumin (MESH:D003474), xanthan gum (MESH:C002563), Aqua (MESH:D014867), sodium gluconate (MESH:C030691), sodium perborate (MESH:C027707), epinephrine (MESH:D004837), sodium saccharin (MESH:D012439), Oxygen (MESH:D010100), proline (MESH:D011392)
- **Species:** Tannerella forsythia (species) [taxon 28112], Homo sapiens (human, species) [taxon 9606], Fusobacterium (genus) [taxon 848], Porphyromonas gingivalis (species) [taxon 837], Capnocytophaga (genus) [taxon 1016], Haemophilus (genus) [taxon 724], Treponema denticola (species) [taxon 158]
- **Cell lines:** H202 — Homo sapiens (Human), Melanoma, Cancer cell line (CVCL_D746)

## Full text

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## References

26 references — full list in the complete paper: https://tomesphere.com/paper/PMC12954727/full.md

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Source: https://tomesphere.com/paper/PMC12954727