# Healthy Dietary Patterns and Risk of Major Eye Diseases: Evidence From Nationally Population‐Based Data and Bibliometric Analysis

**Authors:** Kunhong Xiao, Jiajia Gao, Yiyan Zhang, Ruiye Chen, Yuqing Wang, Chufeng Gu, Jiahao Liu, Yan Huang, Li Li

PMC · DOI: 10.1002/fsn3.71528 · Food Science & Nutrition · 2026-03-03

## TL;DR

This study found that following healthy diets like HEI-2020, DASH, and Mediterranean is linked to a lower risk of major eye diseases.

## Contribution

The study provides new evidence linking specific dietary patterns to reduced risk of retinopathy and composite eye diseases.

## Key findings

- Higher HEI-2020 scores were associated with lower odds of retinopathy and composite eye disease outcomes.
- Greater adherence to the DASH diet was inversely associated with retinopathy and composite eye disease outcomes.
- Mediterranean diet adherence was linked to reduced retinopathy risk and non-linear cataract risk.

## Abstract

The associations between dietary patterns and major eye diseases remain incompletely understood. This study conducted a cross‐sectional analysis of 4241 participants from the 2005–2008 National Health and Nutrition Examination Survey. Eye diseases were assessed using fundus photography and self‐reported information, while dietary patterns were evaluated based on two 24‐h dietary recalls. Survey‐weighted logistic regression and restricted cubic spline models were applied with adjustment for complex sampling design and relevant covariates, alongside subgroup and dietary component–specific analyses. In fully adjusted models, higher HEI‐2020 scores were associated with lower odds of retinopathy and composite eye disease outcomes with or without cataract surgery. Similarly, greater adherence to the DASH was inversely associated with retinopathy and composite eye disease outcomes. Mediterranean diet adherence was also associated with reduced odds of retinopathy, and a non‐linear association was observed between Mediterranean diet adherence and cataract risk. Subgroup analyses indicated effect modification by age, body mass index, alcohol consumption, and hyperlipidemia status. Whole grains, total vegetables, and nuts emerged as protective dietary components, whereas refined grains were identified as a potential risk factor. In conclusion, higher adherence to HEI‐2020, DASH, and Mediterranean dietary patterns was associated with a lower prevalence of selected major eye diseases. These findings reflect associations rather than causation, and prospective studies and randomized trials are needed to clarify temporal and causal relationships.

This study found that higher adherence to HEI‐2020, DASH, and Mediterranean dietary patterns was associated with a lower prevalence of selected major eye diseases.

## Linked entities

- **Diseases:** retinopathy (MONDO:0005283), cataract (MONDO:0005129)

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, COL9A3 (collagen type IX alpha 3 chain) [NCBI Gene 1299] {aka DJ885L7.4.1, EDM3, IDD, MED, STL6}
- **Diseases:** AMD (MESH:D008268), pigmentary abnormalities (MESH:C536859), cancers (MESH:D009369), diabetes (MESH:D003920), Blindness and Vision Impairment (MESH:D014786), dyslipidemia (MESH:D050171), drusen (MESH:D015593), DII (MESH:D007249), degenerative eye disease (MESH:D019636), Disease (MESH:D004194), metabolic syndrome (MESH:D024821), hyperlipidemia (MESH:D006949), Blindness (MESH:D001766), subretinal fibrosis (MESH:D000080363), metabolic abnormalities (MESH:D008659), choroidal neovascularization (MESH:D020256), retinopathy (MESH:D058437), geographic atrophy (MESH:D057092), Age (MESH:D019588), CVD (MESH:D002318), Diabetic Retinopathy (MESH:D003930), GBD 2019 (MESH:D000086382), Hypertension (MESH:D006973), microvascular damage (MESH:D017566), chronic (MESH:D002908), Eye diseases (MESH:D005128), glaucoma (MESH:D005901), retinal damage (MESH:D012164), underweight (MESH:D013851), Cataract (MESH:D002386), type 2 diabetes (MESH:D003924)
- **Chemicals:** omega-3 fatty acid (MESH:D015525), vitamin E (MESH:D014810), sugars (MESH:D000073893), fat (MESH:D005223), vitamin C (MESH:D001205), AGEs (MESH:D017127), carotenoids (MESH:D002338), alpha-linolenic acid (MESH:D017962), fatty acids (MESH:D005227), carbohydrates (MESH:D002241), polyunsaturated fatty acids (MESH:D005231), sodium (MESH:D012964), blood lipids (-), magnesium (MESH:D008274), glucose (MESH:D005947), Alcohol (MESH:D000438), lipid (MESH:D008055), beta-carotene (MESH:D019207), polyphenols (MESH:D059808)
- **Species:** Homo sapiens (human, species) [taxon 9606], gut metagenome (species) [taxon 749906]

## Full text

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## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12954465/full.md

## References

60 references — full list in the complete paper: https://tomesphere.com/paper/PMC12954465/full.md

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Source: https://tomesphere.com/paper/PMC12954465