# The geroscience hypothesis: Economic paradigms and pharmacological strategies for healthspan extension

**Authors:** Adel F. Alotaibi, Areej I. Aljasser, Abdullah N. Alkattan, Ahmed Alkhoraisi, Abdullah M. Assiri

PMC · DOI: 10.1016/j.jtumed.2026.02.004 · Journal of Taibah University Medical Sciences · 2026-02-25

## Full-text entities

- **Genes:** PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1) [NCBI Gene 5564] {aka AMPK, HAMPKb}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}
- **Diseases:** chronic kidney disease (MESH:D051436), inflammatory (MESH:D007249), insulin resistance (MESH:D007333), idiopathic pulmonary fibrosis (MESH:D054990)
- **Chemicals:** Metformin (MESH:D008687), Rapamycin (MESH:D020123), quercetin (MESH:D011794), NR (MESH:C018613), NAD+ (MESH:D009243), NMN (MESH:D009537), dasatinib (MESH:D000069439), D + Q (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12954315/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12954315/full.md

---
Source: https://tomesphere.com/paper/PMC12954315