# Hallmarks of the pre-disease state: prevention and control of the pre-disease state, a tipping point between health and disease

**Authors:** Pei Chen, Xiaoping Liu, Rui Liu, Luonan Chen

PMC · DOI: 10.1038/s41421-026-00879-4 · Cell Discovery · 2026-03-03

## Full-text entities

- **Genes:** KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845] {aka 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A}, STK11 (serine/threonine kinase 11) [NCBI Gene 6794] {aka LKB1, PJS, hLKB1}
- **Diseases:** myocardial infarction (MESH:D009203), CSD (MESH:C566023), chronic diseases (MESH:D002908), DNBs (MESH:D000092242), diabetes (MESH:D003920), cancers (MESH:D009369), lung cancer (MESH:D008175), stroke (MESH:D020521), acute organ failure (MESH:D058186)
- **Chemicals:** DNBs (-)

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## References

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Source: https://tomesphere.com/paper/PMC12953875