# Application and efficacy of Retzius-sparing robotic-assisted radical prostatectomy

**Authors:** Zhicheng Zeng, Faxiong Zhang, Neng Luo, Yalin Li, Xiaofeng Zou, Hui Xu

PMC · DOI: 10.3389/fsurg.2026.1774133 · Frontiers in Surgery · 2026-02-17

## TL;DR

This study compares two robotic prostate surgery methods and finds one helps patients regain bladder control faster.

## Contribution

RS-RARP shows better early urinary continence recovery compared to standard RARP in prostate cancer patients.

## Key findings

- RS-RARP group had significantly better early urinary continence recovery rates compared to S-RARP.
- No significant differences in operation time, blood loss, or complication rates between the two groups.
- Third-month urinary continence recovery rates were not significantly different between the groups.

## Abstract

The results of comparing standard Robotic-assisted Radical Prostatectomy (S-RARP) and Retzius-sparing Robotic-assisted Radical Prostatectomy (RS-RARP) in treating early urinary continence (UC), oncological outcomes, operation time, and perioperative morbidity in patients with clinically localized prostate cancer were analyzed.

A retrospective analysis was conducted on the clinical data of 120 cases of RS-RARP performed at the First Affiliated Hospital of Gannan Medical University from October 2019 to March 2025. Among them, 60 cases underwent standard Robotic-assisted Radical Prostatectomy (S-RARP), and 60 cases underwent Retzius-sparing Robotic-assisted Radical Prostatectomy (RS-RARP). The clinical data, perioperative indicators, and surgical outcomes of the two groups of patients were compared.

All 120 surgeries were successfully completed. The operation time (mean ± SD) of the S-RARP group was (138.97 ± 47.24) minutes, and that of the RS-RARP group was (150.78 ± 51.72) minutes. There was no statistically significant difference (P > 0.05). The intraoperative blood loss (IQR) of the S-RARP group was 100.00 (237.50) mL, and the incidence of perioperative complications was 8.33% (5/60); for the RS-RARP group, it was 100.00 (150.00) mL and 6.67% (4/60), and the differences between the two groups were not statistically significant (all P > 0.05). The positive rate of surgical margins in the S-RARP group was 30% (18/60), and that in the RS-RARP group was 35% (21/60), and the difference was not statistically significant (P > 0.05). Comparisons of the immediate, first-week, and first-month urinary continence recovery rates between the two groups showed that the RS-RARP group was superior to the S-RARP group, and the differences were statistically significant (all P < 0.01); however, the third-month urinary continence recovery rate showed no statistically significant difference (P = 0.057).

Retzius-sparing Robotic-assisted Radical Prostatectomy is beneficial for improving the early recovery of urinary incontinence in patients.

## Linked entities

- **Diseases:** prostate cancer (MONDO:0005159)

## Full-text entities

- **Genes:** KLK3 (kallikrein related peptidase 3) [NCBI Gene 354] {aka APS, KLK2A1, PSA, hK3}
- **Diseases:** respiratory failure (MESH:D012131), bleeding (MESH:D006470), brachial plexus nerve injury (MESH:D020516), pulmonary infection (MESH:D012141), Prostate Cancer (MESH:D011471), mental disorders (MESH:D001523), tumor (MESH:D009369), intestinal obstruction (MESH:D007415), cardiac or pulmonary dysfunction (MESH:D006331), cognitive impairments (MESH:D003072), sepsis (MESH:D018805), urinary incontinence (MESH:D014549), blood (MESH:D006402), tumor metastasis (MESH:D009362), deep vein thrombosis (MESH:D020246), infections (MESH:D007239), cardiovascular, pulmonary or systemic diseases (MESH:D002318)
- **Chemicals:** water (MESH:D014867), CO2 (MESH:D002245), RARP (-), S (MESH:D013455)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12953507/full.md

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Source: https://tomesphere.com/paper/PMC12953507