# Linking ADHD to Depression in Adolescents: the Mediating Role of Social Skills

**Authors:** Allison M. Loomis, Sierra R. Hightower-Henson, Steven W. Evans, George J. DuPaul

PMC · DOI: 10.1007/s10802-026-01430-5 · Research on Child and Adolescent Psychopathology · 2026-03-02

## TL;DR

This study explores how poor social skills in adolescents with ADHD may lead to depression, showing that certain social skills act as a link between ADHD symptoms and depression.

## Contribution

The study identifies specific social skill factors that mediate the relationship between ADHD symptom severity and depression in adolescents.

## Key findings

- Global social skills mediate the relationship between ADHD and depression.
- Specific social skills like cooperation, communication, and empathy mediate the link between ADHD and depression.
- Global social skills also mediate the relationship between ADHD and negative self-evaluation.

## Abstract

Adolescents with attention-deficit/hyperactivity disorder (ADHD) are at a higher risk for developing depression than their peers. One potential explanation for this increased risk is that adolescents with ADHD often have impaired social skills, which may interfere with successful social interactions and connections, and subsequently lead to low self-worth and depression. We hypothesized that global social skills and social skill factors most related to friendships (communication, cooperation, engagement, and empathy) would mediate the positive relation between ADHD symptom severity and depression. Additionally, we investigated whether global social skills would mediate the relations between ADHD symptom severity and four facets of depression (negative self-evaluation, anhedonia, dysphoric mood, and somatic complaints). Our sample included 335 adolescents with ADHD in grades 6–11 who participated in an intervention study. Parent-reported ADHD symptoms were measured at or before baseline, parent-reported social skills (global and several subscales) were measured one year later, and self-reported depression was measured 1.5 years after baseline. Global social skills mediated (1) the relation between ADHD and depression and (2) the relation between ADHD and negative self-evaluation. Cooperation, communication, empathy, and responsibility individually mediated the relation between ADHD and depression, and assertion, self-control, and engagement did not.

The online version contains supplementary material available at 10.1007/s10802-026-01430-5.

## Linked entities

- **Diseases:** ADHD (MONDO:0007743), depression (MONDO:0002050)

## Full-text entities

- **Genes:** ENO2 (enolase 2) [NCBI Gene 2026] {aka HEL-S-279, NSE}
- **Diseases:** pervasive development disorder (MESH:D002659), Hyperactivity (MESH:D006948), MDD (MESH:D003865), loss of energy (MESH:D011502), fatigue (MESH:D005221), Social skill deficits (MESH:D019957), DM (MESH:D009223), anxiety (MESH:D001007), Disruptive Behavior Disorders (MESH:D019958), Mental Disorders (MESH:D001523), substance dependence (MESH:D019966), diminished (MESH:D015354), externalizing disorders (MESH:D017577), Anhedonia (MESH:D059445), inattention and (MESH:D001308), Somatic Complaints (MESH:D013001), emotional (MESH:D003072), internalizing (MESH:D000082122), conduct problems (MESH:D019973), aggression (MESH:D010554), Dysphoric (MESH:C565864), bipolar disorder (MESH:D001714), hyperactive/impulsive (MESH:D007174), Depression (MESH:D003866), obsessive-compulsive disorder (MESH:D009771), Social impairment (OMIM:300082), psychosis (MESH:D011618), ADHD (MESH:D001289), psychomotor slowing (MESH:D011596), DSM-III (MESH:C537189)
- **Species:** Nicotiana tabacum (American tobacco, species) [taxon 4097], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12953414/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12953414/full.md

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Source: https://tomesphere.com/paper/PMC12953414