# Case Report: Intractable hiccups induced by gallbladder necrosis after laparoscopic distal D2 radical gastrectomy: two cases report

**Authors:** Zhi Zhao, Jinquan Lin

PMC · DOI: 10.3389/fsurg.2026.1744253 · Frontiers in Surgery · 2026-02-17

## TL;DR

This case report describes two rare instances of intractable hiccups caused by gallbladder necrosis after gastrectomy and their successful treatment.

## Contribution

The paper is the first to report clinical features and management of intractable hiccups due to gallbladder necrosis post-gastrectomy.

## Key findings

- Intractable hiccups after gastrectomy can be caused by gallbladder necrosis.
- Abdominal CT showing gallbladder enlargement should prompt consideration of gallbladder necrosis.
- Cholecystectomy or ultrasound-guided drainage effectively treated the condition.

## Abstract

Gallbladder necrosis after gastrectomy is very rare, and intractable hiccups caused by gallbladder necrosis is even more rare. Its clinical presentations and management strategies have not been described in available literature. This report firstly describes the clinical presentations, cause, management strategies, and treatment outcome of intractable hiccups immediately after gastrectomy. When intractable hiccups occurs after gastrectomy and abdominal computed tomography (CT) indicates gallbladder enlargement, gallbladder necrosis should be considered. After cholecystectomy or ultrasound-guided percutaneous gallbladder drainage, the patients were successfully treated.

## Linked entities

- **Diseases:** intractable hiccups (MONDO:0018334)

## Full-text entities

- **Diseases:** gallstones (MESH:D042882), cancer (MESH:D009369), edema (MESH:D004487), Gallbladder necrosis (MESH:D005705), inflammation (MESH:D007249), abscess (MESH:D000038), muscle tension (MESH:D018781), gastric antral adenocarcinoma (MESH:D020252), involuntary paroxysmal spasms (MESH:D002819), hemorrhage (MESH:D006470), GC (MESH:D013274), lymphatic leak (MESH:D008206), diaphragm (MESH:D065630), cholecystitis (MESH:D002764), peritonitis (MESH:D010538), effusion (MESH:D000080324), leukocytosis (MESH:D007964), anastomotic leakage (MESH:D057868), artery injury (MESH:D057772), ascites (MESH:D001201), hyperbilirubinemia (MESH:D006932), gastric dilation (MESH:D013271), hiccup (MESH:D006606), pancreatic fistula (MESH:D010185), abdominal tenderness (MESH:D000007), ileus (MESH:D045823), tenderness (MESH:D063806)
- **Chemicals:** bilirubin (MESH:D001663), HE (MESH:D006371), metoclopramide (MESH:D008787), chlorpromazine (MESH:D002746)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12953366/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12953366/full.md

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Source: https://tomesphere.com/paper/PMC12953366