# Dementia and hearing loss: from risk to mechanisms and management

**Authors:** Emma E. Broome, Sian Calvert, Eithne Heffernan, Helen Henshaw, Aaliyah Khan, Vassilis Pelekanos, Joseph Sollini, Jack Stancel-Lewis, Tom Dening

PMC · DOI: 10.3389/frdem.2026.1736003 · Frontiers in Dementia · 2026-02-17

## TL;DR

Midlife hearing loss increases dementia risk, but the mechanisms are unclear, and this review explores the evidence and potential interventions.

## Contribution

This review critically evaluates the evidence linking hearing loss to dementia and highlights the need for integrated care and diverse research populations.

## Key findings

- Hearing loss in midlife is a modifiable risk factor for dementia.
- Current evidence on mechanisms linking hearing loss and dementia is inconclusive.
- Hearing interventions may help modify cognitive decline and dementia risk.

## Abstract

Hearing loss in midlife is an important and potentially modifiable risk factor for the development of dementia. Research examining the association between dementia and hearing loss has expanded rapidly; however, evidence for the mechanisms linking the two conditions is inconclusive, limiting the development of targeted interventions. This review provides a critical overview of current evidence on dementia risk in relation to hearing loss, proposed mechanisms underpinning this association, and emerging evidence on the effectiveness of hearing interventions in modifying trajectories of cognitive decline, dementia risk, and disease progression. Alongside its role as a risk factor, hearing loss commonly co-occurs with dementia, highlighting the need for integrated approaches to care that address the considerable impact of these co-morbid conditions on individuals and communities. Finally, we emphasise the importance of including diverse populations in future research to improve generalisability of findings and help advance equity in dementia prevention and care.

## Linked entities

- **Diseases:** dementia (MONDO:0001627), hearing loss (MONDO:0005365)

## Full-text entities

- **Genes:** APOE (apolipoprotein E) [NCBI Gene 348] {aka AD2, APO-E, ApoE4, LDLCQ5, LPG}, MAPT (microtubule associated protein tau) [NCBI Gene 4137] {aka DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1}, APP (amyloid beta precursor protein) [NCBI Gene 351] {aka AAA, ABETA, ABPP, AD1, APPI, CTFgamma}
- **Diseases:** sensory (MESH:D009477), Sensory deprivation (MESH:D012892), white matter hyperintensities (MESH:D056784), TD (MESH:D004409), depression (MESH:D003866), Dementia (MESH:D003704), HAs (MESH:D034381), Cerebral small vessel disease (MESH:D059345), PSP (MESH:D020920), Cognitive decline (MESH:D003072), speech-in-noise hearing impairment (MESH:D006317), neurofibrillary tangles (MESH:D055956), neurodegeneration (MESH:D019636), inflammation (MESH:D007249), microvascular disease (MESH:D017566), Cerebral hypoperfusion (MESH:D002547), auditory processing disorder (MESH:D001308), brain insults (MESH:D001927), vascular dementia (MESH:D015140), vision loss (MESH:D014786), Mitochondrial dysfunction (MESH:D028361), problems with central auditory function (MESH:D001304), AD (MESH:D000544), functional decline (MESH:D060825), brain atrophy (MESH:C566985), Vascular disease (MESH:D014652), Temporal lobe atrophy (MESH:D004833), traumatic brain injury (MESH:D000070642), vascular dysfunction (MESH:D002561), Impaired auditory input (MESH:D006311), ageing (MESH:D019588), neuroinflammation (MESH:D000090862)
- **Chemicals:** lipid (MESH:D008055), GABA (MESH:D005680), alcohol (MESH:D000438), glutamate (MESH:D018698), glucose (MESH:D005947)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12953099/full.md

## References

146 references — full list in the complete paper: https://tomesphere.com/paper/PMC12953099/full.md

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Source: https://tomesphere.com/paper/PMC12953099