# Robotic versus traditional laparoendoscopic single-site radical hysterectomy with no-manipulation technique: a retrospective cohort study

**Authors:** Yu Chen, Lusi Deng, Jianhong Liu, Fan Yang, Qiao Wang, Sijing Chen, Xu Yang, Ying Zheng

PMC · DOI: 10.3389/fonc.2026.1643025 · Frontiers in Oncology · 2026-02-17

## TL;DR

This study compares robotic and traditional single-site radical hysterectomy techniques for cervical cancer, finding that both are safe and effective, with robotic surgery offering better surgical outcomes.

## Contribution

The study evaluates the robotic approach's advantages over traditional single-site radical hysterectomy in early-stage cervical cancer.

## Key findings

- Robotic surgery had shorter operative time, less blood loss, and shorter drainage time compared to traditional surgery.
- Both groups showed comparable 3-year disease-free and overall survival rates.
- Robotic surgery tended to have fewer conversions and complications.

## Abstract

Controversies and challenges over minimally invasive approach in performing radical hysterectomy for early-stage cervical cancer have been raised. This study aimed to determine whether robotic approach was superior to traditional single-site radical hysterectomy with no-manipulation technique for early-stage cervical cancer.

Patients diagnosed with FIGO 2018 stage IB1, IB2 or IIA1 cervical cancer who underwent robotic or traditional single-site radical hysterectomy and pelvic lymphadenectomy between April 2019 and December 2023 were enrolled to assess the perioperative and survival outcomes.

73 patients were included in the robotic group and 51 cases in the traditional group. The robotic group had significantly shorter operative time (236.5 ± 52.8 vs 390.8 ± 73.5 min, p<0.001), less blood loss (50.0 vs 150.0 mL, p<0.001), and shorter drainage time (3.7 ± 1.2 vs 4.7 ± 1.9 days, p=0.001), with a tendency of less conversions and complications compared to the traditional group. The two groups exhibited comparable 3-year disease-free survival (89.8% vs 95.8%, p=0.399) and overall survival (95.8% vs 96.3%, p=0.752) rates.

Robotic and traditional single-site radical hysterectomies with no-manipulation techniques are both feasible and safe for early-stage cervical cancer with comparable survival outcomes, though longer follow-up is needed to confirm non-inferiority. The robotic system could significantly reduce surgical difficulties and improve perioperative outcomes.

## Linked entities

- **Diseases:** cervical cancer (MONDO:0002974)

## Full-text entities

- **Diseases:** hematoma (MESH:D006406), bowel injuries (MESH:D012778), complication (MESH:D008107), pain (MESH:D010146), Cervical Cancer (MESH:D002583), postoperative pain (MESH:D010149), Cancer (MESH:D009369), EBL (MESH:D016063), ureteral fistula (MESH:D014515), bleeding (MESH:D006470), fever (MESH:D005334), bladder injury (MESH:D001745), ischemia (MESH:D007511), cervical lesion (MESH:D002575), squamous carcinoma (MESH:D002294), bone metastasis (MESH:D009362), synchronous malignancies (MESH:D009378), blood (MESH:D006402), death (MESH:D003643), Urinary injuries (MESH:D014548), infected (MESH:D007239), vascular injuries (MESH:D057772), LVSI (MESH:D008207), PLND (MESH:D000072717), pelvic effusions (MESH:D034161), perforation (MESH:D057112), fistula (MESH:D005402), necrosis (MESH:D009336), Urogenital fistula (MESH:D000091642), MIS (MESH:D009361)
- **Chemicals:** indocyanine (-), CO2 (MESH:D002245), formalin (MESH:D005557)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12953065/full.md

## References

27 references — full list in the complete paper: https://tomesphere.com/paper/PMC12953065/full.md

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Source: https://tomesphere.com/paper/PMC12953065