# Intradural Extramedullary Thoracic Spinal Paraganglioma in a Young Adult: A Case Report

**Authors:** Serge E Bambule, Tarik Chekrine, Mouna Bourhafour, Medhi Karkouri, Souha Sahraoui

PMC · DOI: 10.7759/cureus.102734 · Cureus · 2026-01-31

## TL;DR

A young adult had a rare spinal tumor removed and recovered well after surgery and radiotherapy.

## Contribution

This case report presents a rare instance of intradural extramedullary thoracic spinal paraganglioma in a young adult.

## Key findings

- The patient showed complete recovery of motor deficits after functional rehabilitation.
- Radiological follow-up showed no signs of tumor recurrence one year post-radiotherapy.

## Abstract

Spinal paragangliomas are rare, typically benign neuroendocrine tumors, exceptionally uncommon in the intradural extramedullary thoracic region. Their diagnosis is particularly unusual in young adults. We report the case of a 27-year-old patient who presented with progressive paraparesis due to spinal cord compression caused by a 36 × 17 mm mass at the D3-D4 level, identified on MRI. Surgical resection was performed. Pathological examination confirmed the diagnosis of spinal paraganglioma, supported by immunohistochemistry (positive for chromogranin A, synaptophysin, and focal expression of S-100 protein). Given the risk of local recurrence, adjuvant radiotherapy was administered. Clinical outcome was favorable, with complete recovery of motor deficits following functional rehabilitation. Radiological follow-up at one year post-radiotherapy showed no signs of recurrence.

## Full-text entities

- **Genes:** DBH (dopamine beta-hydroxylase) [NCBI Gene 1621] {aka DBM, ORTHYP1}, SDHC (succinate dehydrogenase complex subunit C) [NCBI Gene 6391] {aka CYB560, CYBL, PGL3, PPGL3, QPS1, SDH3}, RET (ret proto-oncogene) [NCBI Gene 5979] {aka CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1}, SDHB (succinate dehydrogenase complex iron sulfur subunit B) [NCBI Gene 6390] {aka CWS2, IP, MC2DN4, PGL4, PPGL4, SDH}, TH (tyrosine hydroxylase) [NCBI Gene 7054] {aka DYT14, DYT5b, TYH}, S100B (S100 calcium binding protein B) [NCBI Gene 6285] {aka NEF, S100, S100-B, S100beta}, SDHD (succinate dehydrogenase complex subunit D) [NCBI Gene 6392] {aka CBT1, CII-4, CWS3, MC2DN3, PGL, PGL1}, CHGA (chromogranin A) [NCBI Gene 1113] {aka CGA, PHE5, PHES}, SYP (synaptophysin) [NCBI Gene 6855] {aka MRX96, MRXSYP, XLID96}, VHL (von Hippel-Lindau tumor suppressor) [NCBI Gene 7428] {aka HRCA1, RCA1, VHL1, pVHL}
- **Diseases:** myelopathy (MESH:D013118), neuroendocrine tumors (MESH:D018358), spinal cord compression (MESH:D013117), spinal (MESH:D013122), motor deficits (MESH:D009461), lower (MESH:D017116), hypervascular lesions (MESH:D009059), Paraganglioma (MESH:D010235), Hemorrhagic tumor (MESH:D009369), sensory disturbances (MESH:D012678), lower-limb weakness (MESH:D018908), sphincter dysfunction (MESH:D046628), schwannomas (MESH:D009442), headaches (MESH:D006261), localized pain (MESH:D010146), paraparesis (MESH:D020335), palpitations (MESH:D006331), toxicity (MESH:D064420), metastases (MESH:D009362), subarachnoid infiltration (MESH:D013345), meningiomas (MESH:D008579), hypertension (MESH:D006973)
- **Chemicals:** octreotide (MESH:D015282), metanephrines (MESH:D008676), 68Ga-DOTATATE (MESH:C513399), eosin (MESH:D004801), normetanephrines (MESH:D009647), 18 F-Dopa (MESH:C043437), catecholamine (MESH:D002395), MIBG (MESH:D019797), 18-FDG (-), hematoxylin (MESH:D006416)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12952856/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12952856/full.md

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Source: https://tomesphere.com/paper/PMC12952856