# A Complex Case of Unilateral Stasis Dermatitis With Id Reaction Misdiagnosed as Cellulitis: A Diagnostic Challenge

**Authors:** Sandra M Johnson, Youkyung S Roh, Sima Rozati

PMC · DOI: 10.7759/cureus.104555 · Cureus · 2026-03-02

## TL;DR

A case of stasis dermatitis with an id reaction was misdiagnosed as cellulitis, highlighting the importance of accurate diagnosis to avoid unnecessary treatments.

## Contribution

Highlights a rare diagnostic challenge involving stasis dermatitis and autoeczematization misdiagnosed as cellulitis.

## Key findings

- Autoeczematization can mimic cellulitis and lead to misdiagnosis.
- Accurate diagnosis prevented unnecessary systemic therapies in this case.
- Management with compression and topical corticosteroids resolved the condition.

## Abstract

Autoeczematization, or id reaction, is a secondary eczematous eruption occurring at sites distant from a primary inflammatory skin process. It is often underrecognized in patients with stasis dermatitis and can mimic cellulitis or drug-induced eruptions. A male in his 50s with plaque psoriasis and a history of heavy smoking (55 pack years) presented with acute unilateral left leg erythema and edema, initially treated as recurrent cellulitis. He subsequently developed a diffuse, pruritic morbilliform eruption on the trunk and extremities. Biopsies revealed chronic spongiotic dermatitis in the leg and nonspecific spongiotic changes in the trunk. Imaging and cultures excluded infection or abscess. The eruption was diagnosed as autoeczematization secondary to stasis dermatitis. Topical corticosteroids, compression therapy, leg elevation, and skin care led to the gradual resolution of both local and widespread lesions. Clinicians should consider venous stasis in cases of unilateral leg swelling and recognize autoeczematization as a potential complication. Timely and accurate diagnosis can prevent unnecessary systemic therapies, with management focused on compression, topical corticosteroids, and supportive skin care.

## Linked entities

- **Diseases:** psoriasis (MONDO:0005083), cellulitis (MONDO:0005230)

## Full-text entities

- **Genes:** IL4 (interleukin 4) [NCBI Gene 3565] {aka BCGF-1, BCGF1, BSF-1, BSF1, IL-4}, IL31 (interleukin 31) [NCBI Gene 386653] {aka IL-31}, IL13 (interleukin 13) [NCBI Gene 3596] {aka IL-13, P600}
- **Diseases:** dermatophyte infections (MESH:D003881), plaque psoriasis (MESH:D011565), atopic dermatitis (MESH:D003876), erythema (MESH:D004890), fever (MESH:D005334), vesicular eruption (MESH:D012872), infectious (MESH:D003141), chronic (MESH:D002908), tissue injury (MESH:D017695), venous stasis (MESH:D054070), pruritus (MESH:D011537), dermal (MESH:D016136), unilateral leg swelling (MESH:D046088), smoking (MESH:D015208), abdominal rash (MESH:D000007), inflammatory skin (MESH:D012878), eczematous (MESH:D017443), autoimmune conditions (MESH:D001327), Cellulitis (MESH:D002481), cutaneous lymphoma (MESH:D008223), pruritic rash (MESH:D005076), varicosities (MESH:D014647), venous congestion (MESH:D006940), osteomyelitis (MESH:D010019), tenderness (MESH:D063806), Stasis dermatitis (MESH:D003872), contact dermatitis (MESH:D003877), lymphedema (MESH:D008209), plaque (MESH:D003773), shin injury (MESH:D058923), scabies (MESH:D012532), infection (MESH:D007239), Chronic venous insufficiency (MESH:D014689), IV hypersensitivity (MESH:D006968), drug eruption (MESH:D003875), allergic contact dermatitis (MESH:D017449), edema (MESH:D004487), bullous pemphigoid (MESH:D010391), dermatologic eruption (MESH:D000168), lichen simplex chronicus (MESH:D009450), thrombosis (MESH:D013927), vein thrombosis (MESH:D012170), myxedema (MESH:D009230), lipodermatosclerosis (MESH:C537026), eczematous inflammation (MESH:D007249), abscess (MESH:D000038), disease (MESH:D004194), LLE injury (MESH:D014947), leg injury (MESH:D007869), vasculitis (MESH:D014657), venous reflux (MESH:D005764), hyperpigmentation (MESH:D017495), dermatoses (MESH:D012871), viral exanthems (MESH:D014777), eczema (MESH:D004485), hypertensive (MESH:D006973), Lower extremity pain (MESH:D010146), leg discoloration (MESH:D014075)
- **Chemicals:** clobetasol (MESH:D002990), creatinine (MESH:D003404), steroid (MESH:D013256), HCTZ (MESH:D006852), triamcinolone (MESH:D014221)
- **Species:** Nicotiana tabacum (American tobacco, species) [taxon 4097], Homo sapiens (human, species) [taxon 9606], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932]

## Full text

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## Figures

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## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12952753/full.md

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Source: https://tomesphere.com/paper/PMC12952753