# Single or double endoloop ligation in laparoscopic appendicectomy: a mixed-methods study of clinical outcomes and surgeon perspectives

**Authors:** Lara Nassar, Miqdad Qandeel, Philobater Awad, Basma Hassan, Lina Alim, Jimena Alvarez Del Castillo Gonzalez, Mustafa Makkiyah, Jasim Al-Musawi

PMC · DOI: 10.1186/s12893-026-03544-5 · BMC Surgery · 2026-02-02

## TL;DR

This study compared single and double endoloop ligation in laparoscopic appendicectomy and found no significant difference in complications, but shorter surgery time with single loops.

## Contribution

The study provides mixed-methods evidence on clinical outcomes and surgeon decision-making for endoloop use in appendicectomy.

## Key findings

- No significant difference in clinically relevant 30-day complications between single and double endoloop groups.
- Single endoloop closure was associated with shorter operative time.
- Surgeon decision-making was influenced by tradition, appendiceal base integrity, and training.

## Abstract

Securing the appendiceal stump is a critical step in laparoscopic appendicectomy, the gold-standard treatment for managing acute appendicitis. Endoloops are widely used in appendiceal stump ligation owing to their simplicity and cost-effectiveness, but practice varies between surgeons in the use of one or two loops. This study aimed to compare outcomes between single and double endoloop closure and to explore surgeon perspectives.

A mixed methods approach was used to compare the use of one or two endoloops. A retrospective cohort analysis included patients undergoing laparoscopic appendicectomy in a UK district general hospital between August 2023 and January 2025, comparing post-operative complications and operating time between single and double endoloop ligation. Overall complications were defined as any complications within the 30-day post-operative period while clinically relevant complications referred to intra-abdominal abscess, stump leak, or stump appendicitis. A focus group of operating surgeons was analysed thematically to explore decision-making factors.

Among 191 patients included, 50 (26%) received a single endoloop and 141 (74%) received two. No statistically significant difference in clinically relevant 30-day complications was observed (12% vs. 9.9%; p = 0.07) with overlapping confidence intervals for all complication outcomes. Operative time was shorter in the single-endoloop group (84 ± 41.5 vs. 108.5 ± 31.9 min; p = 0.004). Thematic analysis identified three key influences on endoloop choice: perceived security through tradition, assessment of appendiceal base integrity, and training considerations.

No statistically significant difference in clinically relevant post-operative complications was observed between single and double endoloop closure, although the study may be underpowered to detect rare events. Single endoloop closure was associated with a shorter operative time, which may be partly confounded by disease severity. Surgical decision-making remains influenced by training culture and tradition rather than evidence-based practice, and full standardisation is challenging given variability in case complexity and surgeon expertise.

The online version contains supplementary material available at 10.1186/s12893-026-03544-5.

## Linked entities

- **Diseases:** acute appendicitis (MONDO:0005649)

## Full-text entities

- **Diseases:** SSI (MESH:D013530), perforation (MESH:D057112), stump leak (MESH:D009437), intra-abdominal collection (MESH:D000082122), gangrene (MESH:D005734), necrotic (MESH:D009336), Intra-abdominal abscess (MESH:D018784), Acute appendicitis (MESH:D001064), leak (MESH:D019559), infection (MESH:D007239), appendix (MESH:D001063), acute respiratory distress syndrome (MESH:D012128), pulmonary embolism (MESH:D011655), incisional hernia (MESH:D000069290), pain (MESH:D010146), ASA (MESH:D056807), seroma (MESH:D049291), appendiceal inflammation (MESH:D007249), Complications (MESH:D008107), diverticulitis (MESH:D004238), lymphoid hyperplasia (MESH:D019310), neoplasm (MESH:D009369)
- **Chemicals:** LA (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12952101/full.md

## References

2 references — full list in the complete paper: https://tomesphere.com/paper/PMC12952101/full.md

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Source: https://tomesphere.com/paper/PMC12952101