# Fine-tuning RIPENING INHIBITOR (RIN) expression by introducing allelic mutations in its promoter using CRISPR/Cas9 multiplex editing

**Authors:** Jiaqi Zhou, Chiu-Ling Yang, Diane M. Beckles

PMC · DOI: 10.1186/s43897-025-00200-z · Molecular Horticulture · 2026-03-02

## Full-text entities

- **Genes:** HY5 [NCBI Gene 543733], DML2 (DNA demethylase 2) [NCBI Gene 101263652] {aka SlDML, SlDML2}
- **Diseases:** WT (MESH:D006969), RIN (MESH:D054179)
- **Chemicals:** agarose (MESH:D012685), RIN (-)
- **Species:** Solanum lycopersicum (tomato, species) [taxon 4081]
- **Mutations:** A22H, A26H, A26A

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12952064/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12952064/full.md

---
Source: https://tomesphere.com/paper/PMC12952064