# Dual-path deep learning framework for accurate and interpretable brain tumor diagnosis

**Authors:** Reham F. Haroun, Hatem A. Khater, Mohamed A. Mohamed, Mohamed G. Abdelfattah

PMC · DOI: 10.1186/s12911-026-03367-7 · BMC Medical Informatics and Decision Making · 2026-02-26

## TL;DR

A new AI framework improves brain tumor diagnosis by combining classification and image retrieval, offering high accuracy and interpretability.

## Contribution

A dual-path deep learning framework that integrates tumor classification and content-based image retrieval for enhanced clinical interpretability.

## Key findings

- The framework achieves 99.71% classification accuracy and 97.74% mean average retrieval precision.
- The Classification-Retrieval Agreement Score (CRAS) shows robust diagnostic consistency with a mean score > 0.96.

## Abstract

Existing frameworks for brain tumor diagnosis often focus on standalone classification or retrieval tasks, limiting clinical interpretability and failing to leverage complementary diagnostic insights. To address this, we propose a novel dual-path deep learning framework that synergistically integrates tumor classification with content-based image retrieval (CBIR). Our approach uniquely combines a lightweight GhostNetV3 backbone with deformable convolutions and a decoupled fully connected (DFC) attention mechanism to simultaneously optimize feature extraction for both tasks. This integration enables dynamic adaptation to irregular tumor morphologies while retrieving visually similar cases, bridging the gap between automated predictions and actionable clinical context. Evaluated on a public T1-weighted contrast-enhanced MRI dataset (233 patients, 3,064 images), the framework achieves state-of-the-art performance: 99.71% classification accuracy (precision/recall/F1 > 0.99) and 97.74% mean average retrieval precision (Prec@10: 99.78%). We further introduce the Classification-Retrieval Agreement Score (CRAS), a novel metric quantifying alignment between classifier predictions and retrieved cases, with a mean score > 0.96 demonstrating robust diagnostic consistency. By enhancing accuracy, interpretability, and computational efficiency, this work advances the clinical viability of AI-driven brain tumor diagnosis.

## Linked entities

- **Diseases:** brain tumor (MONDO:0021211)

## Full-text entities

- **Diseases:** pituitary adenomas (MESH:D010911), Tumor (MESH:D009369), Glioma (MESH:D005910), DFC (MESH:D003240), CRAS (MESH:D008310), Meningioma (MESH:D008579), Brain tumors (MESH:D001932)
- **Chemicals:** DFC (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

10 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12952061/full.md

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Source: https://tomesphere.com/paper/PMC12952061