# Intensive combined balneotherapy and aquatic exercise for knee osteoarthritis: short-term clinical and functional outcomes

**Authors:** Gianluca Regazzo, Paola Contessa, Beatrice Forcato, Maddalena Fornasiero, Matteo Gaiofatto, Manuela Gibellini, Federico Massimo, Erika Venturini, Anna Scanu, Stefano Masiero

PMC · DOI: 10.3389/fmed.2026.1790566 · Frontiers in Medicine · 2026-02-16

## TL;DR

Combining balneotherapy with aquatic exercise in mineral water improves knee osteoarthritis more than balneotherapy alone, especially for pain and mobility.

## Contribution

Demonstrates that combining balneotherapy with aquatic exercise in mineral water provides superior short-term benefits for knee osteoarthritis.

## Key findings

- Combined balneotherapy and aquatic exercise reduced pain intensity by 31% compared to 13% with balneotherapy alone.
- The combined protocol improved active range of motion more consistently than balneotherapy alone.
- Higher BMI and age were associated with reduced mobility gains in patients.

## Abstract

Knee osteoarthritis (OA) is a major cause of global disability, necessitating cost-effective interventions. While balneotherapy and acquatic exercise (AE) are established conservative treatments, evidence regarding their combined efficacy remains limited. This study evaluated the clinical impact of a combined program that include balneotherapy and AE in natural mineral waters - compared to balneotherapy alone in patients with mild-to-moderate knee OA in Health Resorts. Primary outcomes included pain intensity, joint range of motion (AROM/PROM), and functional indices [Western Ontario and McMaster Universities (WOMAC), Lequesne’s Algofunctional Index for Knee (LAI-knee)]. Secondary outcomes encompassed quality of life (Short Form-12) and psychological well-being (Pittsburgh Sleep Quality Index and Psychological General Well-Being Index).

66 patients were allocated to either an experimental group (EG), receiving a combined two-week protocol of balneotherapy and AE in salt-bromine-iodine thermal water, or a control group (CG), receiving balneotherapy alone.

Both groups demonstrated significant short-term improvements in all the assessments included in study. However, the EG exhibited a superior reduction in pain intensity (31% vs. 13% in CG) and more consistent gains in bilateral active range of motion (AROM). Linear mixed-effects models confirmed significant time effects for WOMAC, LAI, and SF-12 Physical Component scores for both groups. Regression analysis revealed that higher BMI and age negatively correlated with mobility gains.

A combined intervention significantly enhances the analgesic and functional benefits of standard balneotherapy. By leveraging physical properties of mineral water, the combined protocol addresses both the mechanical and biological components of knee OA. These findings support the integration of water exercise with balneotherapy in Health Resorts for degenerative joint diseases and the personalization of treatment based on patients age and BMI.

## Full-text entities

- **Diseases:** Knee osteoarthritis (MESH:D020370), joint disorder (MESH:D007592), anxiety (MESH:D001007), psychiatric disease (MESH:D001523), joint effusion (MESH:D000080324), fibromyalgia (MESH:D005356), AROM (MESH:D009041), skin infections (MESH:D007239), neoplasm (MESH:D009369), pain (MESH:D010146), stiffness (MESH:C566112), sleep disturbances (MESH:D012893), PC (MESH:D015324), Parkinson's disease (MESH:D010300), degenerative joint disease (MESH:D019636), wounds (MESH:D014947), chronic synovial inflammation (MESH:D007249), arthritis (MESH:D001168), sarcopenia (MESH:D055948), morning stiffness (MESH:D048968), epilepsy (MESH:D004827), chronic low back pain (MESH:D017116), loss of articular cartilage (MESH:D002357), muscle skeletal disorders (MESH:D005207), OA (MESH:D010003), wear (MESH:D057085), AE (MESH:D000092202), heart, liver, respiratory, or kidney failure (MESH:D012131), musculoskeletal conditions (MESH:D009140), organ dysfunction (MESH:D009102), urinary or fecal incontinence (MESH:D005242), obese (MESH:D009765), depressed mood (MESH:D003866), chronic pain (MESH:D059350)
- **Chemicals:** AE (-), iodide (MESH:D007454), AT (MESH:D001246), mineral waters (MESH:D008900), Water (MESH:D014867)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

56 references — full list in the complete paper: https://tomesphere.com/paper/PMC12951634/full.md

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Source: https://tomesphere.com/paper/PMC12951634