# Case Report: A case of toxic epidermal necrolysis induced by serplulimab: integrated Chinese and Western nursing care

**Authors:** Dan Wang

PMC · DOI: 10.3389/fmed.2026.1759311 · Frontiers in Medicine · 2026-02-16

## TL;DR

A lung cancer patient developed a severe skin reaction to serplulimab and was successfully treated with a combined Chinese and Western nursing approach.

## Contribution

Presents an integrated nursing strategy for managing toxic epidermal necrolysis caused by serplulimab in oncology.

## Key findings

- The patient's widespread skin lesions largely healed after 39 days of treatment.
- No new rashes were observed during the recovery period.
- The patient was discharged in an improved condition following multidisciplinary care.

## Abstract

This study summarizes the integrated Chinese and Western medical nursing experience for a lung cancer patient admitted to our hospital in 2025 who developed toxic epidermal necrolysis (TEN) following treatment with serplulimab. Medical staff provided personalized care addressing the patient’s skin and mucosal lesions, pain, and psychological wellbeing, aiming to establish evidence for the future treatment and management of such symptoms. Following multidisciplinary consultation and 39 days of meticulous treatment and nursing care, the patient’s widespread skin erosion largely healed, with no new rashes observed, ultimately leading to discharge in an improved condition.

## Linked entities

- **Diseases:** lung cancer (MONDO:0005138), toxic epidermal necrolysis (MONDO:0019810)

## Full-text entities

- **Genes:** CD274 (CD274 molecule) [NCBI Gene 29126] {aka ADMIO5, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1}, EGF (epidermal growth factor) [NCBI Gene 1950] {aka HOMG4, URG}, PDCD1 (programmed cell death 1) [NCBI Gene 5133] {aka ADMIO4, AIMTBS, CD279, PD-1, PD1, SLEB2}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}
- **Diseases:** hepatitis (MESH:D056486), drug or food allergies (MESH:D004342), blood stasis (MESH:D014647), pneumonia (MESH:D011014), appetite (MESH:D001068), skin tenderness (MESH:D063806), myocarditis (MESH:D009205), desquamation (MESH:D017490), bacterial infection (MESH:D001424), dryness (MESH:D014987), rash (MESH:D005076), Spleen Deficiency (MESH:D013160), depression (MESH:D003866), mucositis (MESH:D052016), bleeding (MESH:D006470), cutaneous lesions (MESH:D009059), systemic organ failure (MESH:D009102), Itching (MESH:D011537), burn (MESH:D002056), TEN (MESH:D013262), sepsis (MESH:D018805), neurological disorders (MESH:D009461), necrotic (MESH:D009336), Erythema (MESH:D004890), malnutrition (MESH:D044342), ES-SCLC (MESH:D055752), respiratory toxicity (MESH:D012140), Fluid loss (MESH:D002559), blood deficiency (MESH:D006402), Pain (MESH:D010146), Skin lesion (MESH:D012871), Yin Injury (MESH:D016710), hyperpigmentation (MESH:D017495), arthritis (MESH:D001168), inflammation (MESH:D007249), blisters (MESH:D001768), muscle spasms (MESH:D013035), injuries (MESH:D014947), epidermal necrosis (MESH:D004814), overload (MESH:D019190), dermatological (MESH:D000168), drug toxicity (MESH:D064420), orofacial erosion (MESH:D014077), anxiety (MESH:D001007), swelling (MESH:D004487), lung cancer (MESH:D008175), drug eruptions (MESH:D003875), neurological toxicity (MESH:D020258), infection (MESH:D007239), emaciation (MESH:D004614), endocrine system disorders (MESH:D004700), cancer (MESH:D009369), postoperative pain (MESH:D010149), colitis (MESH:D003092), rheumatologic/immune system disorders (MESH:D007154), Poison (MESH:D011041), gastrointestinal toxicity (MESH:D005767)
- **Chemicals:** steroid (MESH:D013256), iodine povidone (MESH:D011206), morphine (MESH:D009020), tramadol (MESH:D014147), ebastine (MESH:C058249), carboplatin (MESH:D016190), Comfrey oil (-), chlorine (MESH:D002713), etoposide (MESH:D005047), loratadine (MESH:D017336), amino acids (MESH:D000596)
- **Species:** Cyperus rotundus (species) [taxon 512623], Coptis chinensis (species) [taxon 261450], Scutellaria baicalensis (Baikal skullcap, species) [taxon 65409], Homo sapiens (human, species) [taxon 9606], Astragalus membranaceus (species) [taxon 649199], Angelica sinensis (Chinese angelica, species) [taxon 165353]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12951628/full.md

## References

43 references — full list in the complete paper: https://tomesphere.com/paper/PMC12951628/full.md

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Source: https://tomesphere.com/paper/PMC12951628