# Mesenteric and Retroperitoneal Mucinous Cystic Neoplasms: A Nongynecologic Process Commonly Managed by Gynecologic Oncologists

**Authors:** Judy Hayek, Jennifer Wolf, Alexandra Hamilton, Yong Mei Yin, Margaux J. Kanis

PMC · DOI: 10.1155/crog/7921200 · Case Reports in Obstetrics and Gynecology · 2026-03-02

## TL;DR

This paper discusses rare non-gynecologic tumors often treated by gynecologic oncologists, highlighting a possible link to diverticulosis.

## Contribution

The study presents a potential correlation between diverticular disease and mesenteric-retroperitoneal mucinous cystic neoplasms.

## Key findings

- Two patients with pelvic masses were diagnosed with mesenteric-retroperitoneal mucinous cystic neoplasms.
- Both patients had diverticulosis and developed diverticulitis during their perioperative course.
- A possible association between diverticular disease and these tumors is suggested.

## Abstract

Retroperitoneal mucinous cystic neoplasm is a rare pathology. Data regarding diagnosis and treatment are limited and based on case reports and series. We describe a case series of two patients each presenting with a pelvic mass suspicious for an adnexal neoplasm. Both were treated surgically with complete resection of the suspected tumor. Pathology from both specimens revealed mesenteric–retroperitoneal mucinous cystic neoplasm. Uniquely, both patients had diverticulosis and their perioperative course was complicated by diverticulitis. We investigate a possible correlation between diverticular disease and the histopathology of mesenteric retroperitoneal mucinous cystic neoplasms.

## Linked entities

- **Diseases:** diverticulitis (MONDO:0004235), mucinous cystic neoplasm (MONDO:0044879)

## Full-text entities

- **Genes:** CDX2 (caudal type homeobox 2) [NCBI Gene 1045] {aka CDX-3, CDX2/AS, CDX3}, PGR (progesterone receptor) [NCBI Gene 5241] {aka NR3C3, PR}, CEACAM3 (CEA cell adhesion molecule 3) [NCBI Gene 1084] {aka CD66D, CEA, CGM1, CGM1a, W264, W282}, EREG (epiregulin) [NCBI Gene 2069] {aka EPR, ER, Ep}, WT1 (WT1 transcription factor) [NCBI Gene 7490] {aka AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1}, KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, KRT7 (keratin 7) [NCBI Gene 3855] {aka CK7, K2C7, K7, SCL}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, CDKN2A (cyclin dependent kinase inhibitor 2A) [NCBI Gene 1029] {aka ARF, CAI2, CDK4I, CDKN2, CMM2, INK4}, NAPSA (napsin A aspartic peptidase) [NCBI Gene 9476] {aka KAP, Kdap, NAP1, NAPA, NR1H2-AS1, SNAPA}, MME (membrane metalloendopeptidase) [NCBI Gene 4311] {aka CALLA, CD10, CMT2T, NEP, SCA43, SFE}, MUC16 (mucin 16, cell surface associated) [NCBI Gene 94025] {aka CA125}
- **Diseases:** cancerous (MESH:D009369), diverticulitis (MESH:D004238), diabetes mellitus (MESH:D003920), lung cancer (MESH:D008175), Cystic Neoplasms (MESH:D018297), carcinomatosis (MESH:D002277), abdominal pain (MESH:D015746), adnexal mass (MESH:D000291), inflammation (MESH:D007249), abscess (MESH:D000038), ovarian cyst (MESH:D010048), H&amp;E (MESH:D016751), endometriosis (MESH:D004715), dysplasia (MESH:D015792), diverticula (MESH:D004240), pelvic mass (MESH:C536030), squamous cell carcinoma of the lung (MESH:D002294), lymphadenopathy (MESH:D008206), diarrhea (MESH:D003967), adnexal neoplasm (MESH:D000292), mucinous (MESH:D002288), ascites (MESH:D001201), back pain (MESH:D001416), adhesions (MESH:D000267), hypertension (MESH:D006973), heterotopic ovarian tissue (MESH:D010049), diverticular disease (MESH:D000076385), mucinous cyst (MESH:D003560), mesenteric-retroperitoneal mucinous cystic neoplasia (MESH:C535553), colonic duplication (MESH:D003108), pelvic (MESH:D034161), fibroid uterus (MESH:D007889), endometrial polyp (MESH:D014591), cystic ovarian neoplasm (MESH:D010051)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12951251/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12951251/full.md

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Source: https://tomesphere.com/paper/PMC12951251