This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
RETRACTION: miR‐107 Regulates Growth and Metastasis of Gastric Cancer Cells via Activation of the PI3K‐AKT Signaling Pathway by Down‐Regulating FAT4
TL;DR
This paper was retracted due to concerns about duplicated figures and inconsistent data, which cast doubt on its conclusions about miR-107's role in gastric cancer.
Contribution
The paper originally claimed miR-107 promotes gastric cancer growth and metastasis by down-regulating FAT4 and activating the PI3K-AKT pathway.
Findings
The paper reported that miR-107 activates the PI3K-AKT pathway in gastric cancer cells.
It claimed miR-107 down-regulates FAT4 to promote cancer growth and metastasis.
The study's conclusions were based on data that could not be verified due to irregularities in figures.
Abstract
RETRACTION: WangL. , LiK. , WangC. , ShiX. , and YangH. , “miR‐107 Regulates Growth and Metastasis of Gastric Cancer Cells via Activation of the PI3K‐AKT Signaling Pathway by Down‐Regulating FAT4,” Cancer Medicine 8, no. 11 (2019): 5264–5273, 10.1002/cam4.2396.31297980 PMC6718591 The above article, published online on 12 July 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by the journal Editor‐in‐Chief, Stephen Tait; and John Wiley & Sons Ltd. Concerns were raised by third parties regarding several areas of overlap in Figures 3A and 3B; duplications in Figure 4; and irregularities with the blots in Figures 1C, 5AB, and 6AB. The authors were unable to provide satisfactory explanations or original data to resolve these concerns. These issues undermine the reliability of the data and the conclusions drawn from the study. The authors have been informed…
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Taxonomy
TopicsHippo pathway signaling and YAP/TAZ · PI3K/AKT/mTOR signaling in cancer · Protein Degradation and Inhibitors
RETRACTION: L. Wang , K. Li , C. Wang , X. Shi , and H. Yang , “miR‐107 Regulates Growth and Metastasis of Gastric Cancer Cells via Activation of the PI3K‐AKT Signaling Pathway by Down‐Regulating FAT4,” Cancer Medicine 8, no. 11 (2019): 5264–5273, 10.1002/cam4.2396.31297980 PMC6718591
The above article, published online on 12 July 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by the journal Editor‐in‐Chief, Stephen Tait; and John Wiley & Sons Ltd. Concerns were raised by third parties regarding several areas of overlap in Figures 3A and 3B; duplications in Figure 4; and irregularities with the blots in Figures 1C, 5AB, and 6AB. The authors were unable to provide satisfactory explanations or original data to resolve these concerns. These issues undermine the reliability of the data and the conclusions drawn from the study.
The authors have been informed about the retraction.