# Lidocaine Injection Provides Superior Pain Relief Compared to 10-Minute BLT Topical Numbing in Women Undergoing Cannula-Based Aesthetic Procedures

**Authors:** Chin-King Looi, Yi Shan Phoon, Lina Pei Shi Yow, Chun-Wai Mai, Tuck Wah Siew

PMC · DOI: 10.1093/asjof/ojag005 · Aesthetic Surgery Journal. Open Forum · 2026-01-20

## TL;DR

This study found that lidocaine injections provide better pain relief than a topical numbing cream during facial aesthetic procedures.

## Contribution

The study compares lidocaine injection and BLT cream for pain management in cannula-based aesthetic procedures and finds lidocaine injection to be more effective.

## Key findings

- Lidocaine injection resulted in significantly lower mean pain scores compared to BLT cream.
- Most patients preferred lidocaine injection for future treatments.
- The difference in pain scores was statistically significant with a mean difference of 2.03.

## Abstract

Despite the growing popularity of aesthetic procedures, procedural pain remains a major concern among patients. Topical numbing cream and local anesthetic injection are widely used to manage discomfort and reduce pain; however, their relative effectiveness in cannula-based facial treatments remains a subject of ongoing debate. The aim of the study was to compare the anesthetic efficacy of BLT cream (benzocaine 20%, lidocaine 10%, and tetracaine 4%) and 1% lidocaine local injection in patients undergoing cannula-based facial aesthetic treatments. Retrospectively, 29 females underwent 2 separate treatment sessions, each using a different anesthetic method. Pain intensity was assessed using a self-reported numerical pain rating scale, and patients were asked to indicate their preferred method upon completion of the second treatment session. Mean pain scores were compared using paired samples t-test, and patient preference was analyzed using frequency and percentage distributions. A P-value of <.05 was considered statistically significant. Of the 29 patients enrolled, 28 patients were included in the final analysis. The mean pain score with BLT cream was 5.07 ± 0.40 (95% CI, 4.24-5.90), compared with 3.04 ± 0.32 (95% CI, 2.38-3.69) with 1% lidocaine injection. The difference was statistically significant (P = .0001), with a mean difference of 2.03. Most patients reported a preference for 1% lidocaine injection over topical cream for future treatments. In this preliminary study, local injection of 1% lidocaine provides significantly better pain control than BLT cream during cannula-based facial treatments, with higher patient preference. Injectable anesthesia may be a more effective option for enhancing patient comfort in aesthetic practice.

Level of Evidence: 3 (Therapeutic)

## Linked entities

- **Chemicals:** benzocaine (PubChem CID 2337), lidocaine (PubChem CID 3676), tetracaine (PubChem CID 5411)

## Full-text entities

- **Diseases:** toxicity (MESH:D064420), anxiety (MESH:D001007), Pain (MESH:D010146), seizures (MESH:D012640), Corneal damage (MESH:D065306), erythema (MESH:D004890), pruritus (MESH:D011537), bruising (MESH:D003288), cardiac arrhythmias (MESH:D001145), allergic reactions (MESH:D004342)
- **Chemicals:** prilocaine (MESH:D011318), tetracaine (MESH:D013748), EMLA (MESH:D000077442), BLT (-), ibuprofen (MESH:D007052), Lidocaine (MESH:D008012), Benzocaine (MESH:D001566), sodium (MESH:D012964), oxygen (MESH:D010100), water (MESH:D014867), lipid (MESH:D008055)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

50 references — full list in the complete paper: https://tomesphere.com/paper/PMC12951079/full.md

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Source: https://tomesphere.com/paper/PMC12951079