# Neonatal Adrenal Hemorrhage Mimicking Suprarenal Tumor in a 12‐Day‐Old With Escherichia coli Urosepsis

**Authors:** Khaled Sawafta, Hani Abu Hijleh, Yousef Samara, Tasbeeh Al-Kharraz

PMC · DOI: 10.1155/crpe/2165402 · Case Reports in Pediatrics · 2026-03-01

## TL;DR

A 12-day-old baby with E. coli infection had an adrenal hemorrhage mistaken for a tumor, but it was managed without surgery.

## Contribution

Highlights adrenal hemorrhage as a rare but important differential diagnosis in septic neonates with abdominal masses.

## Key findings

- Adrenal hemorrhage was incidentally found in a neonate with E. coli urosepsis.
- Conservative treatment with antibiotics and imaging was sufficient without evidence of malignancy.
- The case supports noninvasive management when malignancy is ruled out.

## Abstract

Neonatal adrenal hemorrhage is an uncommon finding that may resemble suprarenal tumors. We describe a term male neonate who developed Escherichia coli urosepsis and was incidentally found to have a left suprarenal cystic lesion. Imaging and laboratory workup excluded malignancy, and the infant remained stable under conservative treatment with antibiotics and serial ultrasound follow‐up. This case emphasizes the need to consider adrenal hemorrhage in septic neonates with abdominal masses and supports noninvasive management in the absence of malignant features.

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, AFP (alpha fetoprotein) [NCBI Gene 174] {aka AFPD, FETA, HPAFP}, CRP [NCBI Gene 20468888]
- **Diseases:** adrenal insufficiency (MESH:D000309), endocrine abnormalities (MESH:D004700), Suprarenal Tumor (MESH:D009369), calcification (MESH:D002114), avascular (MESH:D010020), hypoglycemia (MESH:D007003), infection (MESH:D007239), coagulopathies (MESH:D001778), cystic (MESH:D018297), irritability (MESH:D001523), leukocytosis (MESH:D007964), hydronephrosis (MESH:D006869), birth asphyxia (MESH:D001237), Adrenal Hemorrhage (MESH:D014884), hematomas (MESH:D006406), abscess (MESH:D000038), birth trauma (MESH:D014947), anemia (MESH:D000740), cystic lesion (MESH:D052177), meningococcemia (MESH:D008589), neonatal neuroblastoma (MESH:D009447), adrenal lesion (MESH:D000307), fever (MESH:D005334), septic (MESH:D001170), hyperbilirubinemia (MESH:D006932), hemorrhagic cyst (MESH:D003560), hypoxia (MESH:D000860), infectious (MESH:D003141), Sepsis (MESH:D018805), hemorrhagic adrenal cyst (MESH:C538015), malignant masses (MESH:C536030), hemorrhagic lesions (MESH:D006470), abdominal mass (MESH:D000007), neonatal sepsis (MESH:D000071074), jaundice (MESH:D007565)
- **Chemicals:** cortisol (MESH:D006854), cefotaxime (MESH:D002439), 17-OHP (MESH:D019326), glucose (MESH:D005947), ampicillin (MESH:D000667), DHEA (MESH:D003687)
- **Species:** Homo sapiens (human, species) [taxon 9606], Escherichia coli (E. coli, species) [taxon 562]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12950900/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12950900/full.md

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Source: https://tomesphere.com/paper/PMC12950900