# Case Report: Rare vulvar myofibroblastoma

**Authors:** Jiaxin Miao, Shaoqin Sheng, Xiangqian Xu, Weiwei Qian, Yanying Nong

PMC · DOI: 10.3389/fonc.2026.1750550 · Frontiers in Oncology · 2026-02-16

## TL;DR

This case report describes a rare vulvar tumor called myofibroblastoma in an elderly woman, highlighting the importance of complete surgical removal and long-term monitoring.

## Contribution

The paper presents a rare clinical case of vulvar myofibroblastoma and emphasizes the need for thorough initial surgery and long-term follow-up.

## Key findings

- The patient's tumor was diagnosed as myofibroblastoma with uncertain malignant potential after surgical resection and histopathological analysis.
- Complete initial surgical excision and follow-up imaging were critical in preventing recurrence and ensuring recovery.
- Long-term monitoring is essential due to the tumor's uncertain biological behavior.

## Abstract

Vulvar Myofibroblastoma is a rare mesenchymal tissue tumor originating from myofibroblasts, with an unclear pathogenesis and biological behavior considered to be of uncertain malignant potential or low-grade malignancy. To investigate the clinical and pathological features of vulvar myofibroblastoma, a retrospective study was conducted on a rare case of vulvar myofibroblastoma admitted to Hangzhou Obstetrics and Gynecology Hospital. The patient was an elderly woman who presented with a 3-day history of a vulvar mass. Following initial examination, she underwent vulvar mass resection. Postoperative pathology suggested a myofibroblastic tumor with biological behavior of uncertain malignant potential or low-grade malignancy. As postoperative imaging evaluation indicated residual tumor, the patient subsequently underwent wide local excision of the vulva, which confirmed the diagnosis of vulvar myofibroblastoma. Short-term follow-up showed good recovery with no signs of recurrence or metastasis. In summary, for the diagnosis of rare vulvar myofibroblastoma, imaging examinations can help determine the tumor’s location, size, and relationship with surrounding tissues, but definitive diagnosis relies on histopathology. Treatment should aim for complete resection during the initial surgery. Given the uncertainty of its biological behavior, establishing a strict long-term follow-up mechanism is crucial for monitoring recurrence and ensuring the patient’s long-term prognosis.

## Full-text entities

- **Genes:** SMN1 (survival of motor neuron 1, telomeric) [NCBI Gene 6606] {aka BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3}, CD34 (CD34 molecule) [NCBI Gene 947], VIM (vimentin) [NCBI Gene 7431], STAT6 (signal transducer and activator of transcription 6) [NCBI Gene 6778] {aka D12S1644, HIES6, IL-4-STAT, STAT6B, STAT6C}, PGR (progesterone receptor) [NCBI Gene 5241] {aka NR3C3, PR}, S100B (S100 calcium binding protein B) [NCBI Gene 6285] {aka NEF, S100, S100-B, S100beta}, EREG (epiregulin) [NCBI Gene 2069] {aka EPR, ER, Ep}, CMPK1 (cytidine/uridine monophosphate kinase 1) [NCBI Gene 51727] {aka CK, CMK, CMPK, UMK, UMP-CMPK, UMPK}, DES (desmin) [NCBI Gene 1674] {aka CDCD3, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}, CTNNB1 (catenin beta 1) [NCBI Gene 1499] {aka CTNNB, EVR7, MRD19, NEDSDV, armadillo}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, ALK (ALK receptor tyrosine kinase) [NCBI Gene 238] {aka ALK1, CD246, NBLST3}
- **Diseases:** bleeding (MESH:D006470), Vulvar mesenchymal tumors (MESH:C535700), IMT (MESH:D009369), Vulvar (MESH:D014845), Spindle cell lesion (MESH:D002277), swelling (MESH:D004487), abdominal pain (MESH:D015746), inflammatory (MESH:D007249), SCVM (MESH:D009379), Cervical polyp (MESH:D011127), tenderness (MESH:D063806), metastasis (MESH:D009362), vaginal bleeding (MESH:D014592), inflammatory myofibroblastic fibroblastoma (MESH:D018223), fibrous histiocytoma (MESH:D018219), hypertension (MESH:D006973)
- **Chemicals:** eosin (MESH:D004801), hematoxylin (MESH:D006416)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12950569/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12950569/full.md

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Source: https://tomesphere.com/paper/PMC12950569