# Phytochemical Composition and Therapeutic Potential of Ludwigia adscendens: A Narrative Review

**Authors:** Tasnia Mahmud Easha, Faiza Hamid Jyoti, Farjana Afrin, Mahmuda Nasrin

PMC · DOI: 10.1155/tswj/5359686 · The Scientific World Journal · 2026-03-01

## TL;DR

This review explores the bioactive compounds in Ludwigia adscendens and its potential therapeutic uses for diseases like diabetes and cancer.

## Contribution

The paper provides a comprehensive overview of the phytochemical and pharmacological properties of Ludwigia adscendens.

## Key findings

- Ludwigia adscendens contains bioactive compounds like flavonoids and terpenoids with antioxidant and anti-inflammatory effects.
- The plant shows potential in treating cardiovascular diseases, diabetes, and microbial infections.
- Further clinical studies are needed to confirm its safety and therapeutic efficacy.

## Abstract

Ludwigia adscendens subsp. diffusa, an aquatic plant with an extended tradition of use in conventional healthcare, has received growing recognition for its variety of bioactive compounds. Numerous components, notably flavonoids, phenolics, tannins, alkaloids, and terpenoids, have been shown through phytochemical analyses to be responsible for the plant′s pharmacological effects. These compounds are known to have actions such as antioxidant, anti‐inflammatory, antimicrobial, antidiabetic properties, and anticancer effects. Initial phytochemical and pharmacological screenings have indicated therapeutic potential in addressing cardiovascular diseases, diabetes, and microbial infections; however, the current data are still incomplete. A comprehensive chemical characterization and an extensive assessment of its pharmacological effects are essential for enhancing our comprehension of its curative properties. Whereas in vitro and in vivo findings are promising, further investigation into clinical relevance and safety profiles is necessary to confirm L. adscendens as a potential therapeutic agent.

## Linked entities

- **Diseases:** diabetes (MONDO:0005015), cancer (MONDO:0004992)
- **Species:** Ludwigia adscendens (taxon 1241825)

## Full-text entities

- **Genes:** Sis (sucrase isomaltase) [NCBI Gene 69983] {aka 2010204N08Rik, SI, Si-s}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}
- **Diseases:** wheezing (MESH:D012135), microbial infections (MESH:D015163), hemorrhaging (MESH:D006470), carcinomas of the breast and colon cells (MESH:D001943), inflammatory bowel disease (MESH:D015212), deformities (MESH:D009140), diarrhea (MESH:D003967), strokes (MESH:D020521), pneumonia (MESH:D011014), disorders of the liver (MESH:D017093), paralysis (MESH:D010243), infections of the bladder (MESH:D001745), fever (MESH:D005334), urinary diseases (MESH:D014570), arthritic (MESH:D015535), Water primrose (MESH:C536420), indigestion (MESH:D004415), dysuria (MESH:D053159), prostate cancer (MESH:D011471), dysentery (MESH:D004403), thrombus (MESH:D013927), arthritis (MESH:D001168), Inflammatory (MESH:D007249), viral infections (MESH:D014777), skin disorders (MESH:D012871), pain (MESH:D010146), death (MESH:D003643), diabetes (MESH:D003920), gastrointestinal ailments (MESH:D005767), water (MESH:D000069578), cancer (MESH:D009369), heart attacks (MESH:D009203), snack bites (MESH:D001733), infections (MESH:D007239), cardiovascular diseases (MESH:D002318), Rheumatism (MESH:D012216), asthma (MESH:D001249), renal health (OMIM:603663), cytotoxic (MESH:D064420), urinary tract infections (MESH:D014552)
- **Chemicals:** diclofenac-sodium (MESH:D004008), kaempferol 3-O-rhamnoside (MESH:C470066), myricetin 3-O-rhamnoside (MESH:C529905), CO2 (MESH:D002245), albendazole (MESH:D015766), steroids (MESH:D013256), acetylsalicylic acid (MESH:D001241), protocatechuic acid (MESH:C009091), afzelin (MESH:C477954), water (MESH:D014867), polyphenols (MESH:D059808), betulin (MESH:C002503), squalene (MESH:D013185), quercetin 3-O-galactoside (MESH:C021304), kaempferol 3-O-glucoside (MESH:C511963), terpenes (MESH:D013729), quercetin 3-O-rhamnoside (MESH:C012526), phenolic acids (MESH:C017616), ellagic acid (MESH:D004610), gentamycin (MESH:D005839), lipid membrane (MESH:D008563), acetic acid (MESH:D019342), alkaloids (MESH:D000470), quercetin 3-O-rutinoside (MESH:C404204), alkanes (MESH:D000473), myricetin 3-O-galactoside (MESH:C529904), blood glucose (MESH:D001786), saponins (MESH:D012503), glycosides (MESH:D006027), glucose (MESH:D005947), formalin (MESH:D005557), Flavonoids (MESH:D005419), methanol (MESH:D000432), alloxan (MESH:D000496), octyl gallate (MESH:C016627), silymarin (MESH:D012838), (22E,24R)-6b-hydroxy stigmasta-4,22-dien-3-one (-), ethyl acetate (MESH:C007650), acarbose (MESH:D020909), methyl gallate (MESH:C052082), penicillin (MESH:D010406), n-butanol (MESH:D020001), dihydroquercetin (MESH:C003377), 3,3,4-tri-O-methyl ellagic acid (MESH:C052418), quercetin-3-O-glucoside (MESH:C016527), MTT (MESH:C070243), betulonic acid (MESH:C118308), phytosterols (MESH:D010840), streptomycin (MESH:D013307), betulinic acid (MESH:D000094062), carbohydrate (MESH:D002241), myricitrin (MESH:C008577), DPPH (MESH:C004931), phenols (MESH:D010636), triterpenoids (MESH:D014315), tannins (MESH:D013634)
- **Species:** Penicillium chrysogenum (species) [taxon 5076], Mucor hiemalis (species) [taxon 64493], Haemonchus contortus (barber pole worm, species) [taxon 6289], Escherichia coli (E. coli, species) [taxon 562], Bacillus cereus (species) [taxon 1396], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Mus musculus (house mouse, species) [taxon 10090], Vibrio cholerae (species) [taxon 666], Staphylococcus aureus (species) [taxon 1280], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932], Homo sapiens (human, species) [taxon 9606], Aspergillus niger (species) [taxon 5061], Klebsiella pneumoniae (species) [taxon 573], earthworms (species) [taxon 71170], Ludwigia adscendens (species) [taxon 1241825]
- **Cell lines:** PC-3 — Homo sapiens (Human), Prostate carcinoma, Cancer cell line (CVCL_0035), HeLa — Homo sapiens (Human), Human papillomavirus-related endocervical adenocarcinoma, Cancer cell line (CVCL_0030)

## Full text

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## Figures

30 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12950354/full.md

## References

31 references — full list in the complete paper: https://tomesphere.com/paper/PMC12950354/full.md

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Source: https://tomesphere.com/paper/PMC12950354