# A Fatal Case of Capsular Serovar D of Capnocytophaga canimorsus Infection Following a Dog Bite in a Previously Healthy Adult

**Authors:** Hiroyuki Tanimoto, Hisashi Dote, Hiroki Shinozaki, Yuuki Meguro, Shoko Ishii, Shimon Aoki, Takeaki Nishibori, Kazuki Kobayashi, Mamoru Miyajima

PMC · DOI: 10.7759/cureus.104503 · Cureus · 2026-03-01

## TL;DR

A previously healthy man died rapidly from a rare Capnocytophaga canimorsus infection after a dog bite, likely due to an undiagnosed spleen issue.

## Contribution

This case highlights the rapid progression and fatality of rare C. canimorsus serovar D infection in patients with unrecognized hyposplenism.

## Key findings

- C. canimorsus capsular serovar D was identified post-mortem as the cause of fatal septic shock.
- The patient's unrecognized functional hyposplenism likely contributed to rapid clinical deterioration.
- Systemic symptoms and organ failure occurred within hours of infection presentation.

## Abstract

We report a rapidly fatal case of Capnocytophaga ​​​​canimorsus septic shock with suspected acute infectious purpura fulminans (AIPF) in a 61-year-old man following a dog bite to the finger. Although he appeared previously healthy, retrospective analysis revealed a markedly small spleen (54 mm in diameter) on computed tomography and Howell-Jolly bodies on a peripheral blood smear, indicating unrecognized functional hyposplenism. He developed systemic symptoms within 48 h and progressed to respiratory failure and refractory shock within 1 h of presentation to the emergency department. The blood smear also demonstrated phagocytosed Gram-negative rods, prompting immediate broad-spectrum antimicrobial therapy and intensive care. However, multiple organ failure progressed, and the patient died on hospital day three. C. canimorsus was identified from blood cultures five days after death; capsular serovar D was confirmed subsequently. This case highlights that C. canimorsus infection can trigger explosive clinical deterioration, particularly when uncommon virulent strains like serovar D infect patients with unrecognized splenic atrophy.

## Linked entities

- **Species:** Capnocytophaga canimorsus (taxon 28188)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, FGB (fibrinogen beta chain) [NCBI Gene 2244] {aka HEL-S-78p}
- **Diseases:** ARDS (MESH:D012128), fever (MESH:D005334), erythema (MESH:D004890), AIPF (MESH:D055665), peripheral ischemia (MESH:D007511), hypotension (MESH:D007022), metabolic (MESH:D008659), septic shock (MESH:D012772), sepsis (MESH:D018805), Infectious Diseases (MESH:D003141), vomiting (MESH:D014839), DIC (MESH:D004211), low back pain (MESH:D017116), multiple organ failure (MESH:D009102), respiratory failure (MESH:D012131), leukopenia (MESH:D007970), purpura (MESH:D011693), systemic (MESH:D015619), functional (MESH:D003291), Splenic dysfunction (MESH:D013158), fulminant disease (MESH:D047508), diabetes mellitus (MESH:D003920), adrenal insufficiency (MESH:D000309), metabolic failure (MESH:D051437), hypoglycemia (MESH:D007003), C. canimorsus infection (MESH:D007239), ecchymosis (MESH:D004438), swelling (MESH:D004487), Purpuric lesions (MESH:C537186), atrophy (MESH:D001284), metabolic acidosis (MESH:D000138), anuria (MESH:D001002), toxicity (MESH:D064420), cirrhosis (MESH:D005355), endotoxemia (MESH:D019446), necrotizing fasciitis (MESH:D019115), shock (MESH:D012769), metabolic collapse (MESH:D001261), hepatic dysfunction (MESH:D008107), alcohol use disorder (MESH:D000437), Purpuric skin lesions (MESH:D012871), pain (MESH:D010146), hypertension (MESH:D006973), sore throat (MESH:D010612), death (MESH:D003643)
- **Chemicals:** amlodipine (MESH:D017311), steroid (MESH:D013256), Clindamycin (MESH:D002981), Meropenem (MESH:D000077731), lactate (MESH:D019344), polysaccharide (MESH:D011134), azithromycin (MESH:D017963), oxygen (MESH:D010100)
- **Species:** Capnocytophaga canimorsus (species) [taxon 28188], Felis catus (cat, species) [taxon 9685], Homo sapiens (human, species) [taxon 9606], Canis lupus familiaris (dog, subspecies) [taxon 9615]

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## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12950349/full.md

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Source: https://tomesphere.com/paper/PMC12950349