# Editorial: Integrating genetics and proteomics for drug discovery

**Authors:** Karunakaran Kalesh, Liang Xue

PMC · DOI: 10.3389/fgene.2026.1806492 · Frontiers in Genetics · 2026-02-16

## Full-text entities

- **Genes:** DKC1 (dyskerin pseudouridine synthase 1) [NCBI Gene 1736] {aka CBF5, CHINE1, DKC, DKCX, NAP57, NOLA4}, DCXR (dicarbonyl and L-xylulose reductase) [NCBI Gene 51181] {aka DCR, HCR2, HCRII, KIDCR, P34H, PNTSU}, PUS1 (pseudouridine synthase 1) [NCBI Gene 80324] {aka MLASA1}, ELAC2 (elaC ribonuclease Z 2) [NCBI Gene 60528] {aka COXPD17, ELC2, HPC2}, BRCA2 (BRCA2 DNA repair associated) [NCBI Gene 675] {aka BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD}, PUS7 (pseudouridine synthase 7) [NCBI Gene 54517] {aka IDDABS}, BRCA1 (BRCA1 DNA repair associated) [NCBI Gene 672] {aka BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4}, CPT2 (carnitine palmitoyltransferase 2) [NCBI Gene 1376] {aka CPT1, CPTASE, IIAE4}, ACAT1 (acetyl-CoA acetyltransferase 1) [NCBI Gene 38] {aka ACAT, MAT, T2, THIL}
- **Diseases:** prostatic diseases (MESH:D011469), benign prostatic hyperplasia (MESH:D011470), Tumour (MESH:D009369), epithelial ovarian cancer (MESH:D000077216), homologous recombination deficiency (MESH:C535296), hepatocellular carcinoma (MESH:D006528)
- **Chemicals:** fatty-acid (MESH:D005227), lipid (MESH:D008055)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

3 references — full list in the complete paper: https://tomesphere.com/paper/PMC12950266/full.md

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Source: https://tomesphere.com/paper/PMC12950266