# Incidental Irregular Mass Within a Hamartoma Detected on Breast Ultrasound: A Case Report and Review of the Literature

**Authors:** Christine Tang, Justin H Qian, Miguel A Salinas, Kellen S Carril, Quan D Nguyen

PMC · DOI: 10.7759/cureus.102641 · Cureus · 2026-01-30

## TL;DR

A case report describes a breast mass within a hamartoma that was later identified as a fibroadenoma, highlighting the importance of biopsy for suspicious ultrasound findings.

## Contribution

This case emphasizes the need for biopsy in distinguishing benign and malignant masses within hamartomas.

## Key findings

- A new hypoechoic irregular mass with angular margins was detected 15 months after initial imaging.
- Biopsy confirmed the mass was a fibroadenoma, not a carcinoma.
- Suspicious ultrasound features require biopsy to rule out malignancy.

## Abstract

Mammary hamartomas are heterogeneous breast masses containing glandular epithelium, fibrous tissue, and adipose tissue. The development of a breast carcinoma within a hamartoma is rare. We present the case of a 41-year-old female patient who had an asymptomatic breast mass incidentally discovered on physical exam. Ultrasound indicated a benign-appearing mass encased in a hamartoma. Fifteen months later, follow-up imaging detected a new hypoechoic irregular mass with an angular margin. Further work-up with biopsy identified the mass to be a fibroadenoma. In hypoechoic masses with suspicious features such as irregular shape and angular margins, malignancy cannot be definitively ruled out without a core needle biopsy. Radiological identification of these masses, which appear distinct from heterogeneous hamartomas, allows for early detection of potential carcinomas. To distinguish carcinomas from fibroadenomas, these masses should be biopsied.

## Linked entities

- **Diseases:** breast carcinoma (MONDO:0004989), fibroadenoma (MONDO:0002056)

## Full-text entities

- **Diseases:** FELs (MESH:D018225), invasive ductal carcinoma (MESH:D044584), breast carcinoma (MESH:D001943), Fibroadenomas (MESH:D018226), masses (MESH:C536030), mastitis (MESH:D008413), Mammary hamartomas (MESH:C536818), breast pain (MESH:D059373), phyllodes tumors (MESH:D003557), Hamartoma (MESH:D006222), fibrocystic changes (MESH:D005348), BI-RADS (MESH:D061325), lobular carcinoma in situ (MESH:D000071960), calcification (MESH:D002114), carcinoma (MESH:D009369), ductal carcinoma in situ (MESH:D002285), invasive lobular carcinoma (MESH:D018275)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12950213/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12950213/full.md

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Source: https://tomesphere.com/paper/PMC12950213