# Iron-Catalyzed Stereospecific Heterocycle N‑Glycosylation with Glycal Epoxides

## TL;DR

A new iron-catalyzed method enables efficient and stereospecific N-glycosylation of heterocycles with glycal epoxides, offering useful building blocks for drug discovery.

## Contribution

An iron-catalyzed stereospecific N-glycosylation method for glycal epoxides with high yields and low catalyst loadings.

## Key findings

- The method achieves high yields with low catalyst loadings.
- It is functional-group-tolerant and works for complex glycal epoxides and heterocycles.

## Abstract

Stereospecific N-glycosylation
of heterocycles with glycal epoxides
could readily provide valuable building blocks for drug discovery,
but heterocycle N-glycosylation with a pyranose-based glycal epoxide
is still difficult using existing methods. We report herein an iron-catalyzed
stereospecific heterocycle N-glycosylation method for these glycal
epoxides in high yields with low catalyst loadings. This method is
functional-group-tolerant and effective for a wide variety of functionalized,
complex glycal epoxides and heterocycles.