# Mounier‐Kuhn Syndrome Flare With Pleuritic Chest Pain: A Discussion of Complications and Management

**Authors:** Geran Maule, Akil Augustus, Mohammad Khraisat, Jay Mehta, Elio Rodríguez Araque, Michael D. Schweitzer

PMC · DOI: 10.1155/crpu/7654438 · Case Reports in Pulmonology · 2026-02-27

## TL;DR

This paper discusses a rare lung condition called Mounier-Kuhn Syndrome and its complications, focusing on a case involving chest pain and treatment strategies.

## Contribution

The paper expands understanding of noninfectious complications of Mounier-Kuhn Syndrome and highlights advances in its management.

## Key findings

- A 56-year-old male with MKS experienced pleuritic chest pain and bronchiectasis.
- Conservative treatment improved symptoms, but interventional options like stenting show promise.
- Early diagnosis and multidisciplinary care are critical for managing MKS complications.

## Abstract

Mounier‐Kuhn syndrome (MKS), or tracheobronchomegaly, is a rare disorder characterized by dilation of the trachea and main bronchi due to atrophy of elastic and smooth muscle fibers. It is associated with recurrent respiratory infections, bronchiectasis, and airway collapse. Although radiological diagnosis is well established, clinical recognition remains delayed in many cases due to the disease′s rarity and nonspecific presentation.

We present a 56‐year‐old male with a known history of MKS who presented with pleuritic chest pain, productive cough, and constitutional symptoms. Computed tomography (CT) scans of the chest showed significant tracheobronchomegaly with posterior tracheal diverticulum and cystic bronchiectasis. Laboratory evaluation was unremarkable, and infectious and autoimmune workups were negative. The patient was treated conservatively with pulmonary hygiene, bronchodilators, and symptom‐targeted therapy, leading to gradual improvement.

This case dives into a noninfectious symptomatic flare of MKS, expanding the clinical understanding of its complications. We explore the pathophysiology of pleuritic pain in this setting and review diagnostic delays, bronchiectasis‐related morbidity, and therapeutic strategies. Advances in interventional pulmonology, including airway stenting and tracheobronchoplasty, offer promising outcomes in selected patients. Early identification, structured imaging assessment, and a multidisciplinary approach are key in managing this complex syndrome.

## Linked entities

- **Diseases:** Mounier-Kuhn syndrome (MONDO:0010148), bronchiectasis (MONDO:0004822)

## Full-text entities

- **Genes:** IGHE (immunoglobulin heavy constant epsilon) [NCBI Gene 3497] {aka IgE}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, PRTN3 (proteinase 3) [NCBI Gene 5657] {aka ACPA, AGP7, C-ANCA, CANCA, MBN, MBT}, CD79A (CD79a molecule) [NCBI Gene 973] {aka IGA, IGAlpha, MB-1, MB1}, SERPINA1 (serpin family A member 1) [NCBI Gene 5265] {aka A1A, A1AT, AAT, PI, PI1, PRO2275}, MPO (myeloperoxidase) [NCBI Gene 4353]
- **Diseases:** cutis laxa (MESH:D003483), thromboembolic (MESH:D013923), tracheal diverticulum (MESH:D014133), Chest Pain (MESH:D002637), ankylosing spondylitis (MESH:D013167), dilation of the trachea and main bronchi (MESH:D055089), hemoptysis (MESH:D006469), Marfan's syndrome (MESH:D008382), respiratory compromise (MESH:D012131), Type 2 diabetes mellitus (MESH:D003924), MKS (MESH:D014137), structural disorder (MESH:D020914), autoimmune (MESH:D001327), nausea (MESH:D009325), crackles (MESH:D012135), febrile (MESH:D000071072), hypoxia (MESH:D000860), vomiting (MESH:D014839), ischemia (MESH:D007511), airway abnormalities (MESH:D000402), fevers (MESH:D005334), pulmonary embolism (MESH:D011655), bronchial dilatation (MESH:D001982), atrophy of elastic and smooth muscle fibers (MESH:D018235), tracheal diverticula (MESH:D004240), laryngeal or bronchogenic carcinoma (MESH:D002283), hypertension (MESH:D006973), influenza A/B (MESH:D007251), pain (MESH:D010146), Bronchiectasis (MESH:D001987), II (MESH:C537730), respiratory infections (MESH:D012141), trauma (MESH:D014947), reflux (MESH:D005764), Ehlers-Danlos (MESH:D004535), tracheomalacia (MESH:D055090), airway collapse (MESH:D001261), chronic airway inflammation (MESH:D007249), congenital defect (MESH:D000013), flutter (MESH:D054141), digital clubbing (MESH:D010004), rheumatoid arthritis (MESH:D001172), tracheobronchial abnormalities (MESH:C566362), cough (MESH:D003371), bronchopulmonary infections (MESH:D001997), mitral valve prolapse (MESH:D008945), murmurs (MESH:D006337), Rheumatologic (MESH:D012216), lower extremity swelling (MESH:D004487), chest discomfort (MESH:D013898), atrophy (MESH:D001284), effusion (MESH:D000080324), pulmonary decline (MESH:D060825), pleural abnormalities (MESH:D010995), infection (MESH:D007239), airway dilation (MESH:D002311), dyspnea (MESH:D004417), gastrointestinal complaints (MESH:D005767), ischemic (MESH:D002545), pneumothorax (MESH:D011030)
- **Chemicals:** methocarbamol (MESH:D008721), glucose (MESH:D005947), creatinine (MESH:D003404), budesonide (MESH:D019819), morphine (MESH:D009020), gabapentin (MESH:D000077206), albuterol (MESH:D000420), sodium (MESH:D012964), fluticasone propionate (MESH:D000068298), hypertonic saline (MESH:D012965), guaifenesin (MESH:D006140), mupirocin (MESH:D016712), salmeterol (MESH:D000068299)
- **Species:** Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12949076/full.md

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Source: https://tomesphere.com/paper/PMC12949076