# Nanoparticles‐Mediated Modulation of TRP Channels: Advances and Therapeutic Potential

## TL;DR

This review explores how nanoparticles can control TRP ion channels, offering new ways to develop minimally invasive therapies for various diseases.

## Contribution

The paper systematically reviews the therapeutic potential of nanoparticle-mediated modulation of TRP channels.

## Key findings

- Nanoparticles can activate TRP channels using optical, electrical, and magnetic signals.
- TRP channels are key targets for controlling cell signaling in physiological and pathological contexts.
- Advances in nanotechnology can lead to precise and non-invasive therapeutic strategies.

## Abstract

Nanoparticles have emerged as promising tools for targeting and activating ion channels that serve as transducers for external signals. Their nanoscale dimensions enable targeted activation of ion channels at the cellular or subcellular level, offering unprecedented opportunities to control biological cell signaling. Recent works have demonstrated nanoparticle‐mediated stimulation based on optical, electrical, and magnetic external signals, highlighting their potential to serve as minimally invasive therapeutics. In addition, there is an increasing need to identify relevant ion channels and their physiological role in advancing emerging nanotechnologies. The transient receptor potential (TRP) family, including prominent members such as the TRPV (vanilloid), TRPM (Melastatin), and TRPA (ankyrin), plays critical roles in physiological functions, such as temperature sensation, pain perception, and mechanical stimulus detection, and can be controlled via nanoparticle signaling. This review highlights the properties and roles of dominant TRP family members in different organs and positions them as relevant targets for novel technologies. Leveraging the knowledge of nanoparticle properties with recent advances in pharmacology and disease treatments that target TRP family members will enhance the development of novel nano‐biotechnologies to control cell signaling.

Nanoparticle‐mediated modulation of TRP channels, highlighting the interplay between external stimuli, tailored nanomaterials, and TRP channel activation across a range of physiological contexts. This review examines the roles of TRP channels in cellular signaling and disease, providing insights into how advances in nanotechnology can facilitate precise, minimally invasive therapeutic strategies. Created in https://BioRender.com.