# Exploring microorganism–host interactions: Emerging organoid models and analytical approaches

## TL;DR

This review explores new organoid models and techniques for studying how microorganisms interact with the human body.

## Contribution

The paper highlights the use of newly developed organoid models for studying host-microbe interactions.

## Key findings

- Organoid models derived from human tissues offer advantages over traditional systems.
- Advanced analytical techniques combined with organoids provide deeper insights into host-microbe interactions.
- The paper discusses limitations and effective uses of these models in interaction studies.

## Abstract

Microorganisms play a vital role in human health through their interactions with the body. Studies of host–microbe mechanisms and interactions are crucial for advancing health management. Recently, the organoid‐based models have provided new platforms in this field. Derived from human tissues, these models offer several advantages over traditional systems and, when combined with advanced analytical techniques, they enable deeper insights into host–microbe interactions. In this review, we summarize the different models and techniques used, with a particular focus on the newly developed organoid models. We discuss how these models can be effectively utilized in microorganism–host interaction studies and address their associated limitations.