# Muscle performance but not biomechanics associate with second knee injury in a matched cohort of athletes who passed functional return‐to‐sport criteria after ACL reconstruction

**Authors:** Manuel Angel Romero‐Padron, Neal Weldon, Mazie Atteberry, David Matthew Werner, Tyler Kallman, Matthew Alan Tao, Elizabeth Wellsandt

PMC · DOI: 10.1002/ksa.70245 · Knee Surgery, Sports Traumatology, Arthroscopy · 2025-12-26

## TL;DR

This study finds that muscle performance, not biomechanics, is linked to second knee injuries in athletes who passed return-to-sport tests after ACL surgery.

## Contribution

The study identifies muscle performance as a potential risk factor for second knee injuries, independent of biomechanics.

## Key findings

- Athletes with second knee injuries showed greater quadriceps rate of torque development symmetry.
- Biomechanical measures did not differ between injured and uninjured groups.
- Conventional return-to-sport tests may miss at-risk athletes.

## Abstract

Athletes remain at risk for a second knee injury after anterior cruciate ligament reconstruction (ACLR), even after passing return‐to‐sport (RTS) testing. While biomechanical asymmetries have been linked to reinjury, it is unclear whether deficits persist in athletes who meet RTS criteria. This study compared muscle performance and biomechanical function between athletes who sustained a second knee injury after passing RTS testing and matched controls without reinjury.

In this case‐control study, 11 athletes who returned to their preinjury sport within one year after ACLR, passed RTS testing, and subsequently sustained a second knee injury were matched to controls without reinjury. Muscle performance and biomechanical assessments were conducted within two weeks of passing RTS testing, prior to second knee injuries. Muscle performance was assessed using isometric and isokinetic strength testing on an electromechanical dynamometer. Biomechanical function was evaluated during bilateral drop vertical jumps, unilateral drop vertical jumps, and single‐legged hop for distance using three‐dimensional motion analysis with embedded force platforms. Muscle performance and biomechanical function were compared between limb (injured, uninjured) and group (second knee injury, no second knee injury) using 2 × 2 mixed analyses of variance (ANOVA).

Eight athletes reinjured the ipsilateral knee and three injured the contralateral knee, with reinjury occurring on average 15.4 ± 5.0 months after ACLR. Compared with controls, the second injury group showed greater quadriceps rate of torque development symmetry during early isometric contraction (0–100 ms; p = 0.008). No other significant differences in muscle performance or biomechanical variables were observed.

Greater and more symmetric quadriceps RTD was associated with second knee injury, while biomechanical measures did not differ between groups. These findings suggest that conventional RTS tests may not adequately detect at‐risk athletes after ACLR, and broader assessment strategies may be needed to guide targeted injury prevention.

Level III.

## Full-text entities

- **Diseases:** anterior cruciate ligament (MESH:D000070598), RTD (OMIM:267430), knee injuries (MESH:D007718)

## Full text

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## Figures

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## References

72 references — full list in the complete paper: https://tomesphere.com/paper/PMC12948342/full.md

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Source: https://tomesphere.com/paper/PMC12948342