This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
RETRACTION: Ameliorative Effects of Scopoletin from Crossostephium chinensis against Inflammation Pain and Its Mechanisms in Mice
Evidence-Based Complementary and Alternative Medicine

Abstract
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TopicsMorinda citrifolia extract uses · Magnolia and Illicium research · Medicinal plant effects and applications
RETRACTION: T.‐N. Chang, J.‐S. Deng, Y.‐C. Chang, et al., “Ameliorative Effects of Scopoletin from Crossostephium chinensis against Inflammation Pain and Its Mechanisms in Mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2012 (2012), https://doi.org/10.1155/2012/595603.
The above article, published online on 6 September 2012 in Wiley Online Library (https://wileyonlinelibrary.com), has been retracted by John Wiley & Sons Ltd.
The retraction has been agreed following an investigation of the concerns raised by Actinopolyspora biskrensis on PubPeer [1], which identified several concerns related to Figure 4a. More specifically, the control panel overlaps with the control panels of Figure 6a of [2] and Figure 8a of [3]. Additional similarities have been identified between the Carr panel and the similarly labelled panels in Figure 8a of [4] and Figure 4a of [5].
The experimental conditions for the papers differ in the number of animals used and methods of image acquisition.
As a result of the investigation, the data and conclusions of this article are considered unreliable.
The authors have been informed of this decision but did not provide a response.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Actinopolyspora biskrensis, “Ameliorative Effects of Scopoletin from Crossostephium chinensis against Inflammation Pain and Its Mechanisms in Mice,” Pub Peer, June 2024. https://pubpeer.com/publications/295062 B 75FF 9C 8935667990 C 0A 1FD 4.10.1155/2012/595603 PMC 344358022991572 · doi ↗ · pubmed ↗
- 2Liu S.-L. , Deng J.-S. , Chiu C.-S. et al., Involvement of Heme Oxygenase-1 Participates in Anti-Inflammatory and Analgesic Effects of Aqueous Extract of Hibiscus taiwanensis , Evidence-Based Complementary and Alternative Medicine. (2012) 2012, 10.1155/2012/132859, 2-s 2.0-84863665665.PMC 338851922778769 · doi ↗ · pubmed ↗
- 3Liao J.-C. , Deng J.-S. , Chiu C.-S. et al., Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo, Evidence-Based Complementary and Alternative Medicine. (2012) 2012, 10.1155/2012/429320, 2-s 2.0-84859763499.PMC 331890522536283 · doi ↗ · pubmed ↗
- 4Huang S.-S. , Chiu C.-S. , Chen H.-J. et al., Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice, Evidence-Based Complementary and Alternative Medicine. (2011) 2011, 10.1155/2011/895857, 2-s 2.0-79959259840.PMC 309271521584194 · doi ↗ · pubmed ↗
- 5Huang G.-J. , Liao J.-C. , Chiu C.-S. , Huang S.-S. , Lin T.-H. , and Deng J.-S. , Anti-Inflammatory Activities of Aqueous Extract of Mesona procumbens in Experimental Mice, Journal of the Science of Food and Agriculture. (2012) 92, no. 6, 1186–1193, 10.1002/jsfa.4682, 2-s 2.0-84858706705.22131195 · doi ↗ · pubmed ↗
