# Inflammatory Arthritis Uncovered Through Imaging of Osteonecrosis: A Case Series

**Authors:** Divya Pabbisetti, Anantaram Gudipati, Amber Papalkar, Sandeep Ponnaganti, Kiran Kumar Sailagundla

PMC · DOI: 10.7759/cureus.102491 · Cureus · 2026-01-28

## TL;DR

This study shows that imaging for osteonecrosis can reveal hidden inflammatory arthritis, even without typical symptoms or steroid use.

## Contribution

The paper introduces a novel observation linking inflammatory arthritis to osteonecrosis through imaging findings in patients without steroid history.

## Key findings

- MRI scans in three patients with osteonecrosis revealed signs of undiagnosed inflammatory arthritis.
- Features like synovitis and erosions prompted further evaluation for inflammatory arthritis despite no clinical symptoms.
- None of the patients had a history of steroid use, suggesting a possible new pathophysiological link.

## Abstract

Osteonecrosis (ON) is typically viewed as an isolated condition stemming from vascular compromise. We present a three-case series demonstrating that MRI, performed to confirm the diagnosis of ON, incidentally revealed features consistent with underlying, previously undiagnosed inflammatory arthritis (IA). Even in the absence of typical clinical features, the presence of imaging findings such as synovitis, tenosynovitis, and erosions should prompt a thorough clinical and serological evaluation for coexisting IA. An interesting point to note is that none of the three patients reported a history of steroid use. This manuscript aims to highlight a possible pathophysiological link between IA and ON.

## Linked entities

- **Diseases:** osteonecrosis (MONDO:0005380)

## Full-text entities

- **Genes:** F5 (coagulation factor V) [NCBI Gene 2153] {aka FVL, PCCF, RPRGL1, THPH2, fV}, LPL (lipoprotein lipase) [NCBI Gene 4023] {aka HDLCQ11, LIPD}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, F3 (coagulation factor III, tissue factor) [NCBI Gene 2152] {aka CD142, TF, TFA}
- **Diseases:** sclerosis (MESH:D012598), Hypercoagulable (MESH:D019851), seropositive (MESH:D006679), inflammatory tibialis posterior tenosynovitis (MESH:D037081), Muller-Weiss syndrome (MESH:C537559), systemic lupus erythematosus (MESH:D008180), trauma (MESH:D014947), degenerative changes (MESH:D019636), Kienboch's disease (MESH:D004194), vasculitis (MESH:D014657), Chronic inflammation (MESH:D007249), alcohol abuse (MESH:D000437), fracture (MESH:D050723), ankle pain (MESH:D010146), endarteritis (MESH:D004692), Kienbock's disease (MESH:D010020), endothelial damage (MESH:D014652), ischemic (MESH:D002545), osteonecrosis of the navicular bone (MESH:C536002), BME (MESH:D004487), subluxation of the talar head (MESH:D006258), bone infarction (MESH:D007238), restricted movement (MESH:D002313), necrotic (MESH:D009336), Tenosynovitis (MESH:D013717), joint destruction (MESH:D008105), microvascular dysfunction (MESH:D017566), RA (MESH:D001172), thrombotic (MESH:D013927), collapse (MESH:D001261), IA (MESH:D001168), arterial occlusion (MESH:D001157), synovial (MESH:D013581), Synovitis (MESH:D013585), effusion (MESH:D000080324), Vascular Dysfunction (MESH:D002561), bone erosions (MESH:D014077), arthropathy (MESH:D007592), enthesitis (MESH:D001171)
- **Chemicals:** steroid (MESH:D013256), Depo-Medrol (MESH:D000077555), Lipid (MESH:D008055)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

9 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12947979/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12947979/full.md

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Source: https://tomesphere.com/paper/PMC12947979