This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
RETRACTED: Refolo et al. Chlorogenic Acid Improves the Regorafenib Effects in Human Hepatocellular Carcinoma Cells. Int. J. Mol. Sci. 2018, 19, 1518
Maria Grazia Refolo, Catia Lippolis, Nicola Carella, Aldo Cavallini, Caterina Messa, Rosalba D’Alessandro

Abstract
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsFlavonoids in Medical Research · Cancer Mechanisms and Therapy · Genomics, phytochemicals, and oxidative stress
The Journal retracts the article “Chlorogenic Acid Improves the Regorafenib Effects in Human Hepatocellular Carcinoma Cells” [1] cited above.
Following publication, concerns were brought to the attention of the Editorial Office regarding the integrity of several images presented in this publication [1].
In accordance with the journal’s standard procedures, the Editorial Office and Editorial Board conducted an investigation that confirmed a duplication between sub-panels in Figure 2, as well as a partial duplication of Western blots within Figure 5 and between Figure 5 and Figure 7 in [2], produced by a similar author group, presenting different experimental conditions. The authors fully cooperated with the investigation and indicated that an error had occurred in the collation of the figures. However, as the original images could not be provided for verification, the Editorial Board and the authors were unable to resolve this issue and confirm the reliability of this study. As a Consequence, the Editorial Board has lost confidence in the reliability of the findings and decided to retract this publication [1], as per MDPI’s retraction policy.
This retraction was approved by the Editor-in-Chief of the journal IJMS.
The authors have been informed of this retraction but did not provide a comment on this decision.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Refolo M.G. Lippolis C. Carella N. Cavallini A. Messa C. D’Alessandro R. RETRACTED: Chlorogenic Acid Improves the Regorafenib Effects in Human Hepatocellular Carcinoma Cells Int. J. Mol. Sci.201819151810.3390/ijms 1905151829783729 PMC 5983789 · doi ↗ · pubmed ↗
- 2Refolo M.G. Lotesoriere C. Lolli I.R. Messa M. D’Alessandro R. Molecular mechanisms of synergistic action of Ramucirumab and Paclitaxel in Gastric Cancers cell lines Sci. Rep.202010716210.1038/s 41598-020-64195-x 32346056 PMC 7188894 · doi ↗ · pubmed ↗
