# Seizure Presentation of a Grade II Astrocytoma in a Patient With Ollier's Disease: A Case Report and Brief Review

## TL;DR

A young man with Ollier's disease developed a grade II astrocytoma, highlighting the need for regular brain scans in such patients.

## Contribution

This case report adds to the evidence linking Ollier's disease with astrocytoma and emphasizes the importance of routine MRI screening.

## Key findings

- A 21-year-old patient with Ollier's disease developed a grade II astrocytoma presenting with seizures.
- Literature review identified 12 additional cases of Ollier's disease patients developing astrocytomas.
- Genetic factors like IDH1/2, ATRX, and TP53 mutations are linked to astrocytoma development in Ollier's disease.

## Abstract

Ollier's disease (enchondromatosis) is a dysplasia of cartilage characterized by multiple enchondromas. Current evidence supports a measurable prevalence of concurrent gliomas in patients with Ollier's disease. In patients with Ollier's disease, isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations were shown to be a predisposing factor to the development of astrocytomas in conjunction with subsequent mutations in adenosine triphosphate (ATP)-dependent helicase ATRX (ATRX) and tumor protein p53 (TP53). We present the case report of a 21-year-old man with an adolescent diagnosis of Ollier's disease who developed a grade II astrocytoma in early adulthood. The patient presented to the emergency room with seizures, was given anti-seizure medication, and later underwent chemotherapy and resection of the astrocytomas. A literature review showed 12 additional patients diagnosed with Ollier's disease who were subsequently diagnosed with a grade II astrocytoma later in life. After reviewing the genetics behind Ollier's disease, the importance of performing routine cranial magnetic resonance imaging (MRI) in these patients becomes apparent.