# Point-of-care ultrasound improves the diagnosis of heart failure in patients with dyspnea in primary care

**Authors:** Róbert Kiss-Kovács, Blanka Morvai-Illés, Roland Tóth-Szeles, Ildikó Bakó, András Mohos, Ildikó Ambrus, Luna Gargani, Albert Varga, Gergely Ágoston

PMC · DOI: 10.3389/fmed.2026.1721066 · Frontiers in Medicine · 2026-02-13

## TL;DR

Using point-of-care ultrasound, trained general practitioners can more accurately diagnose heart failure in patients with shortness of breath in primary care settings.

## Contribution

Demonstrates that brief training allows GPs to use PoCUS to significantly improve heart failure diagnostic accuracy in primary care.

## Key findings

- PoCUS improved diagnostic accuracy with 86.8% sensitivity and 88.2% specificity for heart failure.
- Agreement with cardiologist diagnoses increased significantly after PoCUS use.
- B-line quantification and LVEF assessments by GPs correlated strongly with cardiologist results.

## Abstract

Heart failure (HF) is one of the most frequent and clinically important causes of dyspnea, and its recognition in primary care is often hindered by limited access to advanced diagnostics. This study aimed to evaluate whether general practitioners (GPs), after brief training, can use point-of-care ultrasound (PoCUS) to improve the diagnostic accuracy of HF in patients with new-onset dyspnea.

In this prospective validation study, 112 consecutive adult patients with unexplained new-onset dyspnea were initially enrolled across four primary care practices. After clinical evaluation, 102 patients underwent a standardized lung and focused cardiac ultrasound by GPs, using handheld ultrasound machines. B-line quantification and visual assessment of left ventricular ejection fraction (LVEF) were performed. Diagnoses before and after PoCUS were compared to the final diagnosis established by a cardiologist using standard echocardiography. Agreement metrics and diagnostic accuracy measures were calculated.

Post-PoCUS assessments by GPs showed significantly improved diagnostic performance for HF (sensitivity: 86.8%, specificity: 88.2%, positive predictive value: 93.7%, and negative predictive value: 76.5%) compared to pre-PoCUS clinical judgment (sensitivity: 85.3%, specificity: 38.2%, positive predictive value: 73.4%, and negative predictive value: 56.5%). Agreement with the final diagnosis increased substantially (Cohen’s κ from 0.254 to 0.723). GP-assessed B-lines and LVEF correlated strongly with the cardiologist’s results.

A brief, focused training enables GPs to use PoCUS effectively for the detection of HF in patients with dyspnea. Integrating lung and focused cardiac ultrasound into routine primary care may substantially improve diagnostic accuracy, optimize patient management, and reduce unnecessary referrals.

## Linked entities

- **Diseases:** heart failure (MONDO:0005252)

## Full-text entities

- **Genes:** LINC01194 (long intergenic non-protein coding RNA 1194) [NCBI Gene 404663] {aka CT49, TAG}, ACE (angiotensin I converting enzyme) [NCBI Gene 1636] {aka ACE1, CD143, DCP, DCP1}, CD36 (CD36 molecule (CD36 blood group)) [NCBI Gene 948] {aka BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV}, RNF130 (ring finger protein 130) [NCBI Gene 55819] {aka G1RP, G1RZFP, GOLIATH, GP}, P2RY12 (purinergic receptor P2Y12) [NCBI Gene 64805] {aka ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC)}, AP2B1 (adaptor related protein complex 2 subunit beta 1) [NCBI Gene 163] {aka ADTB2, AP105B, AP2-BETA, CLAPB1}, GTPBP1 (GTP binding protein 1) [NCBI Gene 9567] {aka GP-1, GP1, HSPC018, NEDFET1}
- **Diseases:** hypoxemia (MESH:D000860), hypoalbuminemia (MESH:D034141), cardiomyopathy (MESH:D009202), COPD (MESH:D029424), respiratory failure (MESH:D012131), asthma (MESH:D001249), lower-extremity edema (MESH:D004487), chronic kidney disease (MESH:D051436), or anxiety (MESH:D001007), liver cirrhosis (MESH:D008103), LUS (MESH:D008171), valvular heart disease (MESH:D006349), thoracic deformities (MESH:D013896), malignancy (MESH:D009369), Dyspnea (MESH:D004417), nephrotic syndrome (MESH:D009404), respiratory tract infection (MESH:D012141), neuromuscular disorders (MESH:D009468), coronary artery disease (MESH:D003324), interstitial lung disease (MESH:D017563), pulmonary crackles (MESH:D012135), HF (MESH:D006333), renal impairment (MESH:D007674), Atrial fibrillation (MESH:D001281), cardiovascular (MESH:D002318), pulmonary arterial hypertension (MESH:D000081029), hypertensive heart disease (MESH:D006973), lymphangiectasia (MESH:D008201), amyotrophic lateral sclerosis (MESH:D000690), ascites (MESH:D001201), PoCUS (MESH:D003428), anemia (MESH:D000740), Pulmonary congestion (MESH:D001261)
- **Chemicals:** water (MESH:D014867), natriuretic peptide (MESH:D045265), A4Ch (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** S70N

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12947844/full.md

## References

38 references — full list in the complete paper: https://tomesphere.com/paper/PMC12947844/full.md

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Source: https://tomesphere.com/paper/PMC12947844