# Epigastric Pain Caused by Left Upper Quadrant Acute Appendicitis in the Setting of Undiagnosed Intestinal Malrotation

**Authors:** Saher Bhati, Sundareswaran Sharma, Fatma Abdulle, Syed Mohammad Javed

PMC · DOI: 10.7759/cureus.102446 · Cureus · 2026-01-27

## TL;DR

A man in his 40s with epigastric pain was found to have acute appendicitis in an unusual location due to undiagnosed intestinal malrotation.

## Contribution

This case highlights the atypical presentation of appendicitis due to intestinal malrotation and the importance of early CT imaging.

## Key findings

- Acute appendicitis was found in the left upper quadrant due to undiagnosed intestinal malrotation.
- Early CT imaging was critical in identifying the atypical location of the appendicitis.
- The patient recovered fully after laparoscopic appendectomy and treatment for septic shock.

## Abstract

Acute appendicitis is a common surgical emergency that may present atypically due to anatomical variations. We report a case of a previously healthy male in his forties presenting with epigastric abdominal pain, vomiting, and fever, initially managed as gastritis. Contrast-enhanced computed tomography (CT) of the abdomen revealed acute appendicitis in the left upper quadrant on a background of previously undiagnosed intestinal malrotation. The patient underwent emergency laparoscopic appendectomy, with intensive perioperative care for septic shock. He ultimately made a full recovery. This case highlights the importance of maintaining a high index of suspicion for acute appendicitis in adults presenting with epigastric pain and illustrates the role of early CT in identifying atypical presentations caused by underlying anatomical variants.

## Linked entities

- **Diseases:** acute appendicitis (MONDO:0005649), gastritis (MONDO:0004966), intestinal malrotation (MONDO:0008666)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, CRP [NCBI Gene 20468888]
- **Diseases:** infection (MESH:D007239), bacteremia (MESH:D016470), volvulus (MESH:D045822), leukocytosis (MESH:D007964), organomegaly (MESH:D016878), Acute Appendicitis (MESH:D001064), Gastritis (MESH:D005756), septic shock (MESH:D012772), septic (MESH:D001170), rigidity (MESH:D009127), necrosis (MESH:D009336), Sepsis-3 (MESH:D018805), acute abdomen (MESH:D000006), Congenital intestinal malrotation (MESH:C562456), abdominal distension (MESH:D000007), rebound tenderness (MESH:D063806), allergies (MESH:D004342), acute cholecystitis (MESH:D041881), abdominal pain (MESH:D015746), anorexia (MESH:D000855), Small bowel obstruction (MESH:D007409), shock (MESH:D012769), bowel obstruction (MESH:D012778), appendiceal inflammation (MESH:D007249), congenital anomalies (MESH:D000013), Epigastric Pain (MESH:D010146), situs inversus totalis (MESH:D012857), taenia coli (MESH:D013622), hypotension (MESH:D007022), bowel ischemia (MESH:D007511), fever (MESH:D005334), ascending cholangitis (MESH:D002761), emesis (MESH:D014839), analgesia (MESH:D000699), nausea (MESH:D009325), tachycardia (MESH:D013610), jaundice (MESH:D007565)
- **Chemicals:** piperacillin-tazobactam (MESH:D000077725), alcohol (MESH:D000438), phenylephrine (MESH:D010656), lactate (MESH:D019344), metronidazole (MESH:D008795), oxygen (MESH:D010100), norepinephrine (MESH:D009638), ertapenem (MESH:D000077727), meropenem (MESH:D000077731)
- **Species:** Homo sapiens (human, species) [taxon 9606], Escherichia coli (E. coli, species) [taxon 562]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12947602/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12947602/full.md

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Source: https://tomesphere.com/paper/PMC12947602