# Agar-Based Resistive Switching Memory for Neuromorphic Applications

**Authors:** Han-Chiang Chen, I-Chieh Kao, Keng-Jui Lai, Chun-Yen Chen, Yu-Chi Chang

PMC · DOI: 10.1021/acsomega.5c10463 · ACS Omega · 2026-02-12

## TL;DR

A biodegradable memory device made from agar shows stable performance and brain-like behavior, making it suitable for sustainable neuromorphic computing.

## Contribution

A fully biodegradable, forming-free Bio-RRAM using potassium-doped agar with synaptic plasticity for neuromorphic applications.

## Key findings

- The device achieves stable ON/OFF ratios over 10^3 and retention beyond 10^4 seconds.
- It exhibits synaptic plasticity behaviors like potentiation, depression, and multilevel conductance states.
- The design is fully biodegradable and free from complex hybrid structures.

## Abstract

With the growing
demand for sustainable and brain-inspired electronics,
biobased resistive random-access memory (Bio-RRAM) has emerged as
a promising alternative to conventional inorganic devices. However,
most reported Bio-RRAMs still suffer from formation requirements,
unstable ON/OFF ratios, or complex hybrid structures, limiting their
practical use in neuromorphic computing. Here, we demonstrate a potassium-doped
agar Bio-RRAM that overcomes these challenges through a simple, fully
biodegradable design. The optimized device achieves forming-free bipolar
switching, a stable ON/OFF ratio over 103, stable and reproducible
switching cycles, and retention beyond 104 s. More importantly,
the device also exhibits synaptic plasticity behaviors, including
potentiation, depression, paired-pulse facilitation and depression,
and multilevel conductance states, highlighting its feasibility for
neuromorphic computing. These findings demonstrate that agar-based
bioelectronics can serve as a promising route toward next-generation
sustainable memory systems.

## Full-text entities

- **Genes:** AGK (acylglycerol kinase) [NCBI Gene 55750] {aka CATC5, CTRCT38, MTDPS10, MULK}, TRBV20OR9-2 (T cell receptor beta variable 20/OR9-2 (non-functional)) [NCBI Gene 6962] {aka CDR3, TCRBV20S2, TCRBV2O, TCRBV2S2O}
- **Diseases:** PPD (MESH:D003866), LTD (MESH:D000088562), SCLC (MESH:D058747), PPF (MESH:C537238), EPSC (MESH:D020294)
- **Chemicals:** Al (MESH:D000535), Bio (-), ITO (MESH:C109984), K (MESH:D011188), acetone (MESH:D000096), KNO3 (MESH:C023844), water (MESH:D014867), NO3 - (MESH:C038619), methanol (MESH:D000432), chitosan (MESH:D048271), nitrate (MESH:D009566), O (MESH:D010100), pectin (MESH:D010368), polysaccharide (MESH:D011134), N (MESH:D009584), AG (MESH:D000362), polymers (MESH:D011108), C (MESH:D002244)
- **Mutations:** T - T 0

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12947142/full.md

## References

26 references — full list in the complete paper: https://tomesphere.com/paper/PMC12947142/full.md

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Source: https://tomesphere.com/paper/PMC12947142