# Association of Sleeve Gastrectomy With the Management of Ovarian Hyperstimulation Syndrome: A Retrospective Study

**Authors:** Asem Alfagih, Basheer Alkudumani, Zeyad Abualiat, Abdulrahman Alfadhel, Ali H Alsharedah, Tahir Mubarak

PMC · DOI: 10.7759/cureus.102456 · Cureus · 2026-01-28

## TL;DR

This study found that sleeve gastrectomy is linked to longer hospital stays for patients with ovarian hyperstimulation syndrome.

## Contribution

The study provides new evidence on how sleeve gastrectomy affects hospitalization duration in ovarian hyperstimulation syndrome cases.

## Key findings

- Sleeve gastrectomy patients had longer hospital stays (5.3 ± 0.5 days) compared to non-sleeve patients (3.3 ± 2.1 days).
- The difference in hospital stay duration was statistically significant (p = 0.026).
- Reduced oral fluid tolerance after sleeve gastrectomy is hypothesized to contribute to longer hospitalization.

## Abstract

Introduction: The rise in global obesity is a major concern with particular implications for female reproductive health. Obesity is considered a risk factor for menstrual disturbances, female infertility, and reduced success rate of assisted reproductive technologies (ARTs). Weight reduction represents a promising therapeutic approach for addressing infertility in female patients who are obese. Nowadays, bariatric surgery is regarded as the most efficacious long-term intervention for morbid obesity, leading to enhanced reproductive health. The impact of bariatric surgery in terms of association and management has also been sparsely studied, and evidence regarding OHSS management after bariatric surgery is limited, highlighting a literature gap.

Objective: Primarily, this study aimed to investigate the association of sleeve gastrectomy with patients who developed ovarian hyperstimulation syndrome (OHSS) in terms of length of hospital stay.

Results: Interestingly, sleeve gastrectomy patients had longer hospital stays, averaging 5.3 ± 0.5 days, as compared to 3.3 ± 2.1 days among non-sleeve gastrectomy patients (p = 0.026).

Conclusion: The association of sleeve gastrectomy with the management of OHSS manifested as a longer hospital stay. We hypothesize that the reduced oral fluid tolerance after the sleeve gastrectomy may contribute to the increased length of hospital stay.

## Linked entities

- **Diseases:** ovarian hyperstimulation syndrome (MONDO:0011972), obesity (MONDO:0011122)

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, SHBG (sex hormone binding globulin) [NCBI Gene 6462] {aka ABP, SBP, TEBG}, CGA (glycoprotein hormones, alpha polypeptide) [NCBI Gene 1081] {aka CG-ALPHA, FSHA, GPA1, GPHA1, GPHa, HCG}, GNRH1 (gonadotropin releasing hormone 1) [NCBI Gene 2796] {aka GNRH, GRH, LHRH, LNRH}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** chronic kidney disease (MESH:D051436), dyspnea (MESH:D004417), female infertility (MESH:D007247), ET (MESH:D016751), gastroesophageal reflux disease (MESH:D005764), steatotic liver disease (MESH:D008107), inflammation (MESH:D007249), fetal growth restriction (MESH:D005317), metabolic syndrome (MESH:D024821), Osteoarthritis (MESH:D010003), hypercoagulability (MESH:D019851), Obesity (MESH:D009765), Weight (MESH:D015431), OHSS (MESH:D016471), insulin resistance (MESH:D007333), infertility (MESH:D007246), malnutrition (MESH:D044342), Metabolic complications (MESH:D020739), menstrual disturbances (MESH:D004412), atherosclerotic cardiovascular disease (MESH:D050197), anovulation (MESH:D000858), ascites (MESH:D001201), morbid obesity (MESH:D009767), ovarian enlargement (MESH:D010049), thromboembolic (MESH:D013923), type 2 diabetes (MESH:D003924), obstructive sleep apnea (MESH:D020181), hypercholesterolemia (MESH:D006937), abdominal discomfort (MESH:D000007)
- **Chemicals:** E2 (MESH:D004958), progesterone (MESH:D011374), testosterone (MESH:D013739), ART (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

28 references — full list in the complete paper: https://tomesphere.com/paper/PMC12947035/full.md

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Source: https://tomesphere.com/paper/PMC12947035