# Right‐Sided Bilothorax With Secondary Empyema: A Rare Thoracic Manifestation

**Authors:** Aris Sudarwoko, Anna Febriani, Donny Ardika Novananda

PMC · DOI: 10.1155/crpu/3080834 · Case Reports in Pulmonology · 2026-02-27

## TL;DR

A rare case of bile in the right pleural cavity leading to empyema is reported, emphasizing the need for early diagnosis and surgical treatment.

## Contribution

A clinical case report highlighting the management and complications of right-sided bilothorax with secondary empyema.

## Key findings

- Right-sided bilothorax was diagnosed using imaging and a pleural-to-serum bilirubin ratio > 1.
- Surgical repair was required due to persistent pleural discharge and diaphragmatic injury.
- The patient's condition deteriorated despite initial treatment, leading to sepsis and death.

## Abstract

Bilothorax, the presence of bile in the pleural cavity, is a rare and potentially life‐threatening condition. It may occur spontaneously or following hepatobiliary interventions, with right‐sided involvement being most common. Patients are at substantial risk of developing empyema and require prompt drainage and intravenous antibiotic therapy. We report a 41‐year‐old male presenting with progressive dyspnea and bilious pleural effusion. Imaging and pleural fluid analysis confirmed right‐sided bilothorax, supported by a pleural‐to‐serum bilirubin ratio > 1. Cultures later identified Staphylococcus aureus, indicating superimposed empyema. No prior hepatobiliary surgery was documented. Despite initial improvement with antibiotics and drainage, persistent pleural discharge and diaphragmatic injury warranted surgical intervention. Intraoperative findings revealed a 1 cm right hemidiaphragm defect with biliary contamination. Decortication and diaphragmatic repair using an abdominal wall fascial flap were performed. The patient showed clinical improvement postoperatively but declined follow‐up and later succumbed to sepsis. This case highlights the importance of early recognition, appropriate drainage, and timely surgical management for bilothorax complicated by empyema.

## Linked entities

- **Diseases:** empyema (MONDO:0005242)

## Full-text entities

- **Diseases:** pulmonary (MESH:D008171), decreased pleural output (MESH:D002303), diabetes mellitus (MESH:D003920), malignancy (MESH:D009369), chills (MESH:D023341), biliary peritonitis (MESH:D010538), congenital (MESH:D008209), Empyema (MESH:D004653), pleural (MESH:D010995), bilious effusions (MESH:D000080324), dyspnea (MESH:D004417), infection (MESH:D007239), emphysema (MESH:D004646), diaphragmatic injury (MESH:D056989), biliary leak (MESH:D019559), cough (MESH:D003371), abdominal pain (MESH:D015746), weight loss (MESH:D015431), cytotoxic (MESH:D064420), cirrhosis (MESH:D005355), trauma (MESH:D014947), granulomatous inflammation (MESH:D007249), atelectasis (MESH:D001261), abscess (MESH:D000038), gastrointestinal symptoms (MESH:D012817), liver disease (MESH:D008107), hepatomegaly (MESH:D006529), pain (MESH:D010146), suppurative pleuritis (MESH:D010998), malnutrition (MESH:D044342), respiratory distress (MESH:D012128), fever (MESH:D005334), fistula (MESH:D005402), necrosis (MESH:D009336), TB (MESH:D014390), HIV/AIDS (MESH:D015658), hepatic hydrothorax (MESH:D006876), fungal (MESH:D009181), tuberculomas (MESH:D014375), chronic (MESH:D002908), sepsis (MESH:D018805), infectious (MESH:D003141), emphysematous (MESH:D041882), vomiting (MESH:D014839), intra-abdominal (MESH:D000082122), pelvic masses (MESH:C536030), Necrotic tissue (MESH:D017695), nausea (MESH:D009325), abdominal trauma (MESH:D000007), PTBD (MESH:D065634), Microbial infection (MESH:D015163), lymphadenopathy (MESH:D008206), biliary disease (MESH:D001660), pleural effusion (MESH:D010996), biliary fistula (MESH:D001658), tuberculosis (MESH:D014376), pleural discharge (MESH:D019522), diaphragm defect (MESH:D065630), jaundice (MESH:D007565), chest pain (MESH:D002637)
- **Chemicals:** bilirubin (MESH:D001663), metronidazole (MESH:D008795), amikacin (MESH:D000583), cefoperazone-sulbactam (-), hematoxylin (MESH:D006416), beta-lactam (MESH:D047090), eosin (MESH:D004801), levofloxacin (MESH:D064704)
- **Species:** Mycobacterium tuberculosis (species) [taxon 1773], Staphylococcus aureus (species) [taxon 1280], Homo sapiens (human, species) [taxon 9606], Klebsiella pneumoniae (species) [taxon 573], Klebsiella oxytoca (species) [taxon 571], Escherichia coli (E. coli, species) [taxon 562], Enterobacter (genus) [taxon 547], Enterococcus faecalis (species) [taxon 1351]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12946925/full.md

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12946925/full.md

## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12946925/full.md

---
Source: https://tomesphere.com/paper/PMC12946925